Cochlear Inner Hair Cell, Model
Living reference work entry
An algorithmic description of how deflections of the stereocilia in an auditory sensory receptor cell, or cochlear inner hair cell, cause fluctuations in the cell’s intracellular voltage or receptor potential.
Cochlear inner hair cells (IHCs) are auditory sensory receptor cells located in the organ of Corti. They have stereocilia that deflect following mechanical motion of the organ of Corti (Fig. 1). The fluid surrounding the stereocilia bundle, the endolymph, has a positive electrical potential (80–120 mV), while the electrical potential within the IHC is negative at rest (around −60 mV). Stereocilia deflection toward the tallest cilium in the bundle increases the inward flow of positive ions, mostly potassium (K +), and thus increases the cell’s intracellular potential. This mechanism effectively transduces a mechanical signal (stereocilia motion) into an electrical signal (the...
KeywordsHair Cell Auditory Nerve Receptor Potential Endocochlear Potential Transducer Current
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