Short Term Plasticity, Biophysical Models
Short-term plasticity refers to changes in synaptic efficacy in response to presynaptic spiking that persist for a few seconds at most but more often decay over a timescale of a few hundred milliseconds. There are two primary types of short-term plasticity: short-term depression and short-term facilitation. Short-term depression is a reduction in synaptic efficacy that is often, but not always, caused by a transient depletion of neurotransmitter vesicles. Short-term facilitation is an increase in synaptic efficacy often caused by a transient increase in the number of vesicles released by presynaptic action potentials. The detailed biophysical mechanisms underlying synaptic facilitation are discussed in Facilitation, Biophysical Models, and we therefore focus on more phenomenological models of facilitation here.
Stochastic Models of Short-Term Depression Arising from Neurotransmitter Depletion
Short-term depression is often believed to arise primarily...
KeywordsDepression Dock Zucker
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