Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Short Term Plasticity, Biophysical Models

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_358-1


Short-term plasticity refers to changes in synaptic efficacy in response to presynaptic spiking that persist for a few seconds at most but more often decay over a timescale of a few hundred milliseconds. There are two primary types of short-term plasticity: short-term depression and short-term facilitation. Short-term depression is a reduction in synaptic efficacy that is often, but not always, caused by a transient depletion of neurotransmitter vesicles. Short-term facilitation is an increase in synaptic efficacy often caused by a transient increase in the number of vesicles released by presynaptic action potentials. The detailed biophysical mechanisms underlying synaptic facilitation are discussed in Facilitation, Biophysical Models, and we therefore focus on more phenomenological models of facilitation here.

Detailed Description

Stochastic Models of Short-Term Depression Arising from Neurotransmitter Depletion

Short-term depression is often believed to arise primarily...


Deterministic Model Release Site Synaptic Efficacy Docked Vesicle Presynaptic Spike 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Applied and Computational Mathematics and StatisticsUniversity of Notre DameNotre DameUSA