Kinetic Models of Postsynaptic Currents
Modeling synaptic currents and conductances is a central aspect of network simulations. The type of model for synaptic currents depends on the receptor type present in the synapse, as well as if one needs to include mechanisms such as the saturation of successive synaptic events and synaptic depression or facilitation. Kinetic models can provide a way to model these interactions in a compact form and can be analytic in some cases, leading to very fast algorithms to simulate synaptic interactions.
Synaptic currents and conductances represent the most common type of interaction between neurons, and they must be simulated in neuronal networks using the most efficient model as possible. It was shown previously that simplified two-state kinetic models can be used to simulate postsynaptic currents with a reasonable degree of accuracy (Destexhe et al. 1994a, 1998), as an alternative to the more complex Markov models. This approach is similar in...
KeywordsMagnesium Depression Dopamine Serotonin Histamine
- Destexhe A, Mainen M, Sejnowski TJ (1998) Kinetic models of synaptic transmission. In: Koch C, Segev I (eds) Methods in neuronal modeling, 2nd edn. MIT Press, Cambridge, MA, pp 1–26Google Scholar
- Otis TS, De Koninck Y, Mody I (1992) Whole-cell recordings of evoked and spontaneous GABAB responses in hippocampal slices. Pharmacol Commun 2:75–83Google Scholar
- Xiang Z, Greenwood AC, Brown T (1992) Measurement and analysis of hippocampal mossy-fiber synapses (abstract). Soc Neurosci Abstr 18:1350Google Scholar