Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Metabotropic Receptors Dynamics, Conductance Models

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_353-2


A metabotropic receptor is a receptor, usually located on the surface of a cell, that when activated by the binding of transmitter leads to the activation of a secondary messenger system inside the cell. This in turn can induce a conformational change in ion channels in the cell membrane, thus modifying their conductance properties. In many cases, this secondary messenger system involves G-proteins, and thus the term “G-protein-coupled receptor” is often used instead of metabotropic receptor.

Detailed Description

A salient feature of metabotropic receptors is that they act on a much longer timescale (seconds to minutes) than directly gated (ionotropic) receptors, the latter typically acting on a timescale of a few milliseconds. Also, ionotropic receptors act only locally, whereas because of the secondary messenger system, metabotropic receptors can affect the behavior of ion channels in other parts of the cell. Another property is the amplification feature, in that one...


Reversal Potential Channel Conductance Metabotropic Glutamate Receptor GABAB Receptor Receptor Molecule 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.School of Mathematics and StatisticsUniversity of SydneySydneyAustralia