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Reduced Morphology Models

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Encyclopedia of Computational Neuroscience

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Synonyms

Simplified conductance-based models

Definition

Reduced morphology models are simplified computational models obtained by collapsing the dendritic tree of a detailed neuron model, in such a way to preserve as much as possible the original membrane dynamics.

Detailed Description

Morphologically detailed neuron models are based on 3D anatomical cell reconstructions and describe how the spatial dendritic structure of a neuron together with the kinetic properties and distributions of ion channels and synaptic inputs contributes to the dynamics and functionality of a neuron. These compartmental neuron models are usually composed of hundreds of dendritic branches (Fig. 1) with nonlinear membrane properties.

Fig. 1
figure 1

Typical 3D reconstruction of a hippocampal CA1 pyramidal neuron (a) and of a Purkinje cell (b). Both reconstructions were downloaded from the public neuromorpho.org database (cell c70863 and e4cb2a2, respectively)

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Further Reading

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Author information

Authors and Affiliations

  1. Department of Mathematics and Applications, University of Naples Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia, 80126, Naples, Italy

    Dr. Addolorata Marasco

  2. Institute of Biophysics, National Research Council, Palermo, Italy

    Prof. Michele Migliore

Authors
  1. Dr. Addolorata Marasco
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  2. Prof. Michele Migliore
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Corresponding author

Correspondence to Addolorata Marasco .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Marasco, A., Migliore, M. (2014). Reduced Morphology Models. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_245-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_245-1

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  • Online ISBN: 978-1-4614-7320-6

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