Skip to main content

Peripheral Nerves, Anatomy and Physiology of

  • Living reference work entry
  • First Online:

Definition

Peripheral nerves are formed by axonal extensions of neurons in the dorsal root ganglia and spinal cord (spinal nerves), brain stem (cranial nerves), or sympathetic and parasympathetic ganglia (autonomic nerves) that connect the central nervous system (brain and spinal cord) with the rest of the body to maintain homeostasis, mediate sensation, movement, and coordination. The 43 pairs of sensory and motor nerves in the human body are composed of bundles of axons embedded in a collagenous matrix (endoneurium), ensheathed by connective tissue (perineurium), and wrapped by an external connective layer (epineurium). The cellular components of peripheral nerves include Schwann cells, fibroblasts, endothelial-like cells, and macrophages (Stewart, 2003).

Detailed Description

Types of Peripheral Nerves

Peripheral nerves are also classified in reference to the main function that they serve, as either motor sensory or autonomic nerves.

Motor Nerves

This nerves are composed by fibers...

This is a preview of subscription content, log in via an institution.

References

  • Brown MC, Butler RG (1976) Regeneration of afferent and efferent fibres to muscle spindles after nerve injury in adults cats. J Physiol 260(2):253–266

    PubMed  CAS  PubMed Central  Google Scholar 

  • Burgess PR, Horch KW (1973) Specific regeneration of cutaneous fibers in the cat. J Neurophysiol 36(1):101–114

    PubMed  CAS  Google Scholar 

  • Carroll P, Lewin GR, Koltzenburg M, Toyka KV, Thoenen H (1998) A role for BDNF in mechanosensation. Nat Neurosci 1(1):42–46

    Article  PubMed  CAS  Google Scholar 

  • Chen HH, Tourtellotte WG, Frank E (2002) Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons. J Neurosci 22(9):3512–3519

    PubMed  CAS  Google Scholar 

  • Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M (2006) BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair. Exp Neurol 198(2):500–510

    Article  PubMed  CAS  Google Scholar 

  • Fawcett JW, Keynes RJ (1990) Peripheral nerve regeneration. Annu Rev Neurosci 13:43–60

    Article  PubMed  CAS  Google Scholar 

  • Fugleholm K, Schmalbruch H, Krarup C (1994) Early peripheral nerve regeneration after crushing, sectioning, and freeze studied by implanted electrodes in the cat. J Neurosci 14(5 Pt 1):2659–2673

    PubMed  CAS  Google Scholar 

  • Gordon T (2009) The role of neurotrophic factors in nerve regeneration. Neurosurg Focus 26(2):E3

    Article  PubMed  Google Scholar 

  • Hildebrand C, Kocsis JD, Berglund S, Waxman SG (1985) Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Res 358(1–2):163–170

    Article  PubMed  CAS  Google Scholar 

  • Hoke A, Brushart T (2010) Introduction to special issue: challenges and opportunities for regeneration in the peripheral nervous system. Exp Neurol 223(1):1–4

    Article  PubMed  PubMed Central  Google Scholar 

  • Hu X, Cai J, Yang J, Smith GM (2010) Sensory axon targeting is increased by NGF gene therapy within the lesioned adult femoral nerve. Exp Neurol 223(1):153–165

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Kelsey JL, Praemer A, Nelson L et al (1997) Upper extremity disorders. Frequency, impact, and cost. Churchill Livingstone, New York

    Google Scholar 

  • Kiryu-Seo S, Kiyama H (2011) The nuclear events guiding successful nerve regeneration. Front Mol Neurosci 4:53

    Article  PubMed  PubMed Central  Google Scholar 

  • Krarup C, Loeb GE, Pezeshkpour GH (1988) Conduction studies in peripheral cat nerve using implanted electrodes: II. The effects of prolonged constriction on regeneration of crushed nerve fibers. Muscle Nerve 11(9):933–944

    Article  PubMed  CAS  Google Scholar 

  • Madison RD, Archibald SJ, Brushart TM (1996) Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. J Neurosci 16(18):5698–5703

    PubMed  CAS  Google Scholar 

  • Navarro X, Verdu E, Buti M (1994) Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers. Exp Neurol 129(2):217–224

    Article  PubMed  CAS  Google Scholar 

  • Patodia S, Raivich G (2012) Role of transcription factors in peripheral nerve regeneration. Front Mol Neurosci 5:8

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Pfister BJ, Gordon T, Loverde JR, Kochar AS, Mackinnon SE, Cullen DK (2011) Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges. Crit Rev Biomed Eng 39(2):81–124

    Article  PubMed  Google Scholar 

  • Romero MI, Rangappa N, Garry MG, Smith GM (2001) Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy. J Neurosci 21(21):8408–8416

    PubMed  CAS  Google Scholar 

  • Schroder JM (1972) Altered ratio between axon diameter and myelin sheath thickness in regenerated nerve fibers. Brain Res 45(1):49–65

    Article  PubMed  CAS  Google Scholar 

  • Stewart JD (2003) Peripheral nerve fascicles: anatomy and clinical relevance. Muscle Nerve 28(5):525–541

    Article  PubMed  Google Scholar 

  • Tansey KE, Seifert JL, Botterman B, Delgado MR, Romero MI (2011) Peripheral nerve repair through multi-luminal biosynthetic implants. Ann Biomed Eng 39(6):1815–1828

    Article  PubMed  CAS  Google Scholar 

  • Taylor CA, Braza D, Rice JB, Dillingham T (2008) The incidence of peripheral nerve injury in extremity trauma. Am J Phys Med Rehabil 87(5):381–385

    Article  PubMed  Google Scholar 

  • Zheng M, Kuffler DP (2000) Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors. J Neurobiol 42(2):212–219

    Article  PubMed  CAS  Google Scholar 

  • Zochodne DW (2012) The challenges and beauty of peripheral nerve regrowth. J Peripher Nerv Syst 17(1):1–18

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mario Romero-Ortega phD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Romero-Ortega, M. (2014). Peripheral Nerves, Anatomy and Physiology of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_214-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_214-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics