Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Calcium-Dependent Exocytosis, Biophysical Models of

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_178-1

Synonyms

Definition

Calcium-dependent exocytosis is the biochemically controlled fusion of the bilipid secretory vesicle membrane with the bilipid cell membrane, triggered by the binding of several Ca2+ ions to control proteins such as synaptotagmins anchored at the interface between these two membranes. Exocytosis results in the release of vesicle contents into the extracellular space, namely, the release of neurotransmitter into the synaptic cleft in the case of neuronal synapses and neuromuscular junctions or the secretion of hormone into the bloodstream in the case of endocrine cells. Exocytosis also allows the transmembrane proteins contained in the vesicle membrane to be incorporated into the cell membrane, although such membrane protein trafficking is more characteristic of Ca2+-independent, constitutive exocytosis.

Detailed Description

In synapses, neuromuscular junctions, and endocrine cells, fast Ca2+-triggered exocytosis of...

Keywords

Depression Cage Expense Dock Rabie 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Mathematical SciencesNew Jersey Institute of TechnologyNewarkUSA