Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Low-Voltage-Activated Calcium Channels

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_130-2

Synonyms

Definition

Low-voltage-activated (LVA) calcium channels are a class of voltage-gated calcium (Ca2+) channels that exhibit a high probability of opening at hyperpolarized membrane voltages (negative to −50 mV). LVA channels consist of a Cav3 family, of which there are three isoforms (Cav3.1 (α1G), 3.2 (α1H), 3.3 (α1I)). Cav3 channels exhibit a low single-channel conductance and rapid inactivation, resulting in “tiny” and “transient” currents, often termed T-type current or IT. T-type calcium channels were first recognized for their contribution to burst depolarizations and pacemaker activity in specific neurons but are now known to influence a wide range of cell outputs (Huguenard 1996; Perez-Reyes 2003; Yunker and McEnery 2003).

Detailed Description

Several families of Ca2+ channels are expressed in neurons, which can be broadly classified in two groups based on voltage dependence. High-voltage-activated (HVA) Ca2+channels show...

Keywords

Window Current Cav3 Channel Conductance Density Cerebellar Nuclear Neuron Burst Firing Mode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Further Reading

  1. Talavera K, Nilius B (2006) Biophysics and structure-function relationship of T-type Ca2+ channels. Cell Calcium 40:97–114PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Hotchkiss Brain InstituteUniversity of CalgaryCalgaryCanada