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Melanoma pp 249-269 | Cite as

Epidemiology of Melanocytic Neoplasia

  • Margaret Anne TuckerEmail author
Reference work entry

Abstract

Cutaneous melanoma has increased rapidly worldwide over the past 60 years, moving from a rare cancer to one of the most common in the USA. This epidemic has led to epidemiologic and clinical studies to elucidate risk factors for cutaneous melanoma. The risk of melanoma varies by race and ethnicity. Lower socioeconomic status is associated with more advanced melanoma at the time of diagnosis. Identified risk factors for cutaneous melanoma include ultraviolet light exposure (sun and artificial) and host susceptibility factors such as family history of melanoma, dysplastic nevi, increased number of nevi, light pigmentation (skin, hair, and eyes), and immunosuppression. Comprehensive sun/ultraviolet radiation (UV) protection measures, such as those implemented in Australia since the 1990s, are now showing an impact with decreasing incidence of cutaneous melanoma. Mucosal melanoma is distinct from cutaneous melanoma and does not appear to be UV-related. No known risk factors have been identified except for race and gender. Ocular melanoma is also a distinct entity with less evidence of UV exposure as a risk factor than for cutaneous. Host factors include light pigmentation and choroidal/iris nevi. Reciprocal increases in ocular and cutaneous melanoma suggest some common risk factors.

Keywords

Incidence Mortality Survival Risk factors Nevi Cutaneous melanoma Mucosal melanoma Ocular melanoma 

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Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  1. 1.Human Genetics Program, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA

Section editors and affiliations

  • David E. Fisher
    • 1
  • Nick Hayward
    • 2
  • David C. Whiteman
    • 3
  • Keith T. Flaherty
    • 4
  • F. Stephen Hodi
    • 5
    • 6
  • Hensin Tsao
    • 7
    • 8
  • Glenn Merlino
    • 9
  1. 1.Department of Dermatology, Harvard/MGH Cutaneous Biology Research Center, and Melanoma Program, MGH Cancer CenterMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.QIMR Berghofer Medical Research InstituteHerstonAustralia
  3. 3.QIMR Berghofer Medical Research InstituteHerstonAustralia
  4. 4.Henri and Belinda Termeer Center for Targeted TherapiesMGH Cancer CenterBostonUSA
  5. 5.FraminghamUSA
  6. 6.Department of Medicine, Brigham and Women's HospitalDana-Farber Cancer InstituteBostonUSA
  7. 7.AuburndaleUSA
  8. 8.Harvard-MIT Health Sciences and TechnologyCambridgeUSA
  9. 9.Center for Cancer ResearchNational Cancer InstituteBethesdaUSA

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