Melanoma pp 515-534 | Cite as

Management of Locally and Regionally Recurrent Melanoma

  • Cristina O’Donoghue
  • Jonathan S. Zager
  • Vernon K. SondakEmail author
Reference work entry


Locally and regionally recurrent melanoma is a recurrence at the site of primary disease, the regional draining lymph node basin, or in between, described as satellite or in-transit metastases. Close follow-up of melanoma patients is merited as most recurrence is diagnosed from a physical exam. Adjunct imaging is important to determine the extent of disease and to rule out distant metastases. The treatment options for locoregional recurrent melanoma include: surgery, intra-arterial regional therapy, intralesional and topical therapies, radiation and systemic therapies. Factors such as time to recurrence, previous treatments, patient age, recurrence size, location and number should be considered to determine the best treatment option or sequence of options. Patients with melanoma recurrence should be discussed in a multidisciplinary tumor board especially as treatment options continue to develop and evolve.


Melanoma In-transit Satellitosis Intra-arterial therapy Isolated limb infusion Intralesional therapy 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Cristina O’Donoghue
    • 1
  • Jonathan S. Zager
    • 2
  • Vernon K. Sondak
    • 2
    Email author
  1. 1.Department of Surgery, Division of Surgical OncologyRush UniversityChicagoUSA
  2. 2.Department of Cutaneous OncologyMoffitt Cancer CenterTampaUSA

Section editors and affiliations

  • Keith T. Flaherty
    • 1
  • Boris C. Bastian
    • 2
  • Hensin Tsao
    • 3
    • 4
  • F. Stephen Hodi
    • 5
    • 6
  1. 1.Henri and Belinda Termeer Center for Targeted TherapiesMGH Cancer CenterBostonUSA
  2. 2.Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer CenterUniversity of California, San FranciscoSan FranciscoUSA
  3. 3.AuburndaleUSA
  4. 4.Harvard-MIT Health Sciences and TechnologyCambridgeUSA
  5. 5.FraminghamUSA
  6. 6.Department of Medicine, Brigham and Women's HospitalDana-Farber Cancer InstituteBostonUSA

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