Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Spinal Interfaces: Overview

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_785


Spinal stimulation refers to the activation of the spinal cord tissue (white matter axonal tracts and/or gray matter neurons) or associated spinal roots (see “ General Overview of Spinal Anatomy and Physiology Organization” in this Encyclopedia) using various stimulation technologies to restore function lost to neurological impairment or study spinal circuitry organization.

Methodologies to activate spinal tissue can be divided on the basis of applications (bladder, movement restoration, pain reduction, etc.), stimulation or electrode technology employed (electrical, optical, etc.), electrode position (e.g., epidural, intradural, intraspinal, etc.), or a number of other characteristics. In this entry, spinal cord activation techniques are presented based on the degree of invasiveness, and the similar technological methods used to deliver stimulation to the neural tissue are highlighted. In increasing order of invasiveness, spinal cord stimulation techniques can be divided...

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  1. Alilain WJ, Li X, Horn KP, Dhingra R, Dick TE, Herlitze S, Silver J (2008) Light-induced rescue of breathing after spinal cord injury. J Neurosci 28:11862–11870PubMedCentralPubMedGoogle Scholar
  2. Brindley GS (1988) The Ferrier lecture, 1986. The actions of parasympathetic and sympathetic nerves in human micturition, erection and seminal emission, and their restoration in paraplegic patients by implanted electrical stimulators. Proc R Soc Lond B Biol Sci 235:111–120PubMedGoogle Scholar
  3. Edgerton VR, Harkema S (2011) Epidural stimulation of the spinal cord in spinal cord injury: current status and future challenges. Expert Rev Neurother 11:1351–1353PubMedCentralPubMedGoogle Scholar
  4. Egon G, Barat M, Colombel P, Visentin C, Isambert JL, Guerin J (1998) Implantation of anterior sacral root stimulators combined with posterior sacral rhizotomy in spinal injury patients. World J Urol 16:342–349PubMedGoogle Scholar
  5. Fuentes R, Petersson P, Nicolelis MA (2010) Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach. Eur J Neurosci 32:1100–1108PubMedCentralPubMedGoogle Scholar
  6. Gad P, Choe J, Nandra MS, Zhong H, Roy RR, Tai YC, Edgerton VR (2013) Development of a multi-electrode array for spinal cord epidural stimulation to facilitate stepping and standing after a complete spinal cord injury in adult rats. J Neuroeng Rehabil 10:2PubMedCentralPubMedGoogle Scholar
  7. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K (2009) Optical deconstruction of parkinsonian neural circuitry. Science 324:354–359PubMedGoogle Scholar
  8. Harkema S, Gerasimenko Y, Hodes J, Burdick J, Angeli C, Chen Y, Ferreira C, Willhite A, Rejc E, Grossman RG, Edgerton VR (2011) Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet 377:1938–1947PubMedCentralPubMedGoogle Scholar
  9. Izzo AD, Richter CP, Jansen ED, Walsh JT Jr (2006) Laser stimulation of the auditory nerve. Lasers Surg Med 38:745–753PubMedGoogle Scholar
  10. Kim T, Branner A, Gulati T, Giszter SF (2013a) Braided multi-electrode probes: mechanical compliance characteristics and recordings from spinal cords. J Neural Eng 10:045001PubMedCentralPubMedGoogle Scholar
  11. Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y, Song J, Song YM, Pao HA, Kim RH, Lu C, Lee SD, Song IS, Shin G, Al-Hasani R, Kim S, Tan MP, Huang Y, Omenetto FG, Rogers JA, Bruchas MR (2013b) Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science 340:211–216PubMedCentralPubMedGoogle Scholar
  12. Kumar K, Toth C, Nath RK, Laing P (1998) Epidural spinal cord stimulation for treatment of chronic pain-some predictors of success. A 15-year experience. Surg Neurol 50:110–120, discussion 120–111PubMedGoogle Scholar
  13. Ramasubbu C, Flagg A 2, Williams K (2013) Principles of electrical stimulation and dorsal column mapping as it relates to spinal cord stimulation: an overview. Curr Pain Headache Rep 17:315PubMedGoogle Scholar
  14. Ranger MR, Irwin GJ, Bunbury KM, Peutrell JM (2008) Changing body position alters the location of the spinal cord within the vertebral canal: a magnetic resonance imaging study. Br J Anaesth 101:804–809PubMedGoogle Scholar
  15. Saltiel P, Tresch MC, Bizzi E (1998) Spinal cord modular organization and rhythm generation: an NMDA iontophoretic study in the frog. J Neurophysiol 80:2323–2339PubMedGoogle Scholar
  16. Snow S, Horch KW, Mushahwar VK (2006) Intraspinal microstimulation using cylindrical multielectrodes. IEEE Trans Biomed Eng 53:311–319PubMedGoogle Scholar
  17. Wells J, Kao C, Jansen ED, Konrad P, Mahadevan-Jansen A (2005a) Application of infrared light for in vivo neural stimulation. J Biomed Opt 10:064003PubMedGoogle Scholar
  18. Wells J, Kao C, Mariappan K, Albea J, Jansen ED, Konrad P, Mahadevan-Jansen A (2005b) Optical stimulation of neural tissue in vivo. Opt Lett 30:504–506PubMedGoogle Scholar
  19. Wells J, Kao C, Konrad P, Milner T, Kim J, Mahadevan-Jansen A, Jansen ED (2007) Biophysical mechanisms of transient optical stimulation of peripheral nerve. Biophys J 93:2567–2580PubMedCentralPubMedGoogle Scholar
  20. Xia N, Wu XY, Wang X, Mou ZX, Wang MQ, Gu X, Zheng XL, Hou WS (2014) Pulsed 808-nm infrared laser stimulation of the auditory nerve in guinea pig cochlea. Lasers Med Sci 29:343–349PubMedGoogle Scholar
  21. Xiao L, Demosthenous A, Vanhoestenberghe A, Dai J, Donaldson N (2012) Active books: the design of an implantable stimulator that minimizes cable count using integrated circuits very close to electrodes. IEEE Trans Biomed Networks Syst 6:216–227Google Scholar

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of BioengineeringTemple UniversityPhiladelphiaUSA