Detailed Description
Local field potentials (LFPs) are low-frequency electrical potentials recorded with micro- or macro-electrodes throughout the brain. The upper frequency cutoff of the LFP is often considered to be around 100 Hz but may be as high as 500 Hz in some studies. The normal amplitude of the LFP can range from a few microvolts (e.g., in the basal ganglia) (Goldberg et al. 2004) to hundreds of microvolts in the cortex. Perhaps the earliest recording of an LFP may be attributed to Renshaw, Forbes, and Morison in 1940, who described these potentials in the cortex and the hippocampus of a cat under various anesthetics (Renshaw et al. 1940). Extensive electrophysiological studies have formed the current view that cortical LFPs result from synaptic activity (Eccles 1951; Creutzfeldt et al. 1966; Elul 1971; Klee and Rall 1977; Mitzdorf 1985; Bedard et al. 2004). Correspondingly, the LFP fluctuations tend to have a strict phase relationship to cortical discharge: negative...
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References
Abeles M (1982) Local cortical circuits: an electrophysiological study. In: Braitenberg V, Barlow HB, Bullock H, Florey E, Grusser O-J, Peters A (eds). Springer, New York
Bedard C, Kroger H, Destexhe A (2004) Modeling extracellular field potentials and the frequency-filtering properties of extracellular space. Biophys J 86:1829–1842
Bullock TH (1999) Slow potentials in the brain: still little understood but gradually getting analytical attention. Brain Res Bull 50:315–316
Contreras D, Destexhe A, Sejnowski TJ, Steriade M (1997) Spatiotemporal patterns of spindle oscillations in cortex and thalamus. J Neurosci 17:1179–1196
Creutzfeldt OD, Watanabe S, Lux HD (1966) Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity. Electroencephalogr Clin Neurophysiol 20:19–37
Destexhe A, Contreras D, Steriade M (1999) Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states. J Neurosci 19:4595–4608
Donoghue JP, Sanes JN, Hatsopoulos NG, Gaal G (1998) Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements. J Neurophysiol 79:159–173
Eccles JC (1951) Interpretation of action potentials evoked in the cerebral cortex. J Neurophysiol 3:449–464
Eckhorn R, Obermueller A (1993) Single neurons are differently involved in stimulus-specific oscillations in cat visual cortex. Exp Brain Res 95:177–182
Eggermont JJ, Smith GM (1995) Synchrony between single-unit activity and local field potentials in relation to periodicity coding in primary auditory cortex. J Neurophysiol 73:227–245
Elul R (1971) The genesis of the EEG. Int Rev Neurobiol 15:227–272
Goldberg JA, Rokni U, Boraud T, Vaadia E, Bergman H (2004) Spike synchronization in the cortex/basal-ganglia networks of Parkinsonian primates reflects global dynamics of the local field potential. J Neurosci 24(26):6003–6010
Gray CM, Singer W (1989) Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. Proc Natl Acad Sci U S A 86:1698–1702
Klee M, Rall W (1977) Computed potentials of cortically arranged populations of neurons. J Neurophysiol 40:647–666
Lass Y (1968) A quantitative approach to the correlation of slow wave and unit electrical activity in the cerebral cortex of the cat. Electroencephalogr Clin Neurophysiol 25:503–506
Lorente de Nó R (1947) Analysis of the distribution of action currents of nerve in volume conductors. Stud Rockefeller Inst Med Res 132:384–477
Mitzdorf U (1985) Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. Physiol Rev 65:37–100
Murthy VN, Fetz EE (1996a) Oscillatory activity in sensorimotor cortex of awake monkeys: synchronization of local field potentials and relation to behavior. J Neurophysiol 76:3949–3967
Murthy VN, Fetz EE (1996b) Synchronization of neurons during local field potential oscillations in sensorimotor cortex of awake monkeys. J Neurophysiol 76:3968–3982
Renshaw B, Forbes A, Morison BR (1940) Activity of isocortex and hippocampus: electrical studies with micro-electrodes. J Neurophysiol 3(1):74–105
Sanes JN, Donoghue JP (1993) Oscillations in local field potentials of the primate motor cortex during voluntary movement. Proc Natl Acad Sci U S A 90:4470–4474
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Destexhe, A., Goldberg, J.A. (2015). LFP Analysis: Overview. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6675-8_782
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DOI: https://doi.org/10.1007/978-1-4614-6675-8_782
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