Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Endocrine Cell Function and Dysfunction

  • Richard Bertram
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_747

Definition

The endocrine system refers to the cells and tissue that release hormones into the blood. Unlike synaptic chemical communication, which is localized to the target cell, endocrine communication is global. The hormones act on other endocrine glands such as the adrenal gland, ovaries, testes, and others, as well as on the heart, kidneys, muscle, and the brain. Mathematical modeling has been used to understand network interactions mediated by the endocrine system, as well as the effects of hormones on single cells.

Detailed Description

Background

Like neurons, many endocrine cells are electrically excitable and release hormones through Ca2+-mediated exocytosis (Stojilkovic et al. 2010). These have been the focus of mathematical modeling and computer simulation to better understand the mechanisms through which the cells operate. Several endocrine cell types are involved in diseases with substantial morbidity and mortality, making them an important target for model-assisted...

This is a preview of subscription content, log in to check access.

References

  1. Bertram R, Satin L, Zhang M, Smolen P, Sherman A (2004) Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J 87:3074–3087PubMedCentralPubMedGoogle Scholar
  2. Bertram R, Egli M, Toporikova N, Freeman ME (2006) A mathematical model for the mating-induced prolactin rhythm of female rats. Am J Physiol 290:E573–E582Google Scholar
  3. Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A (2007a) Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys J 92:1544–1555PubMedCentralPubMedGoogle Scholar
  4. Bertram R, Sherman A, Satin LS (2007b) Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol 293:E890–E900Google Scholar
  5. Chay TR, Keizer J (1983) Minimal model for membrane oscillations in the pancreatic β-cell. Biophys J 42:181–190PubMedCentralPubMedGoogle Scholar
  6. Sherman A (2010) Lessons from models of pancreatic β cells for engineering glucose-sensing cells. Math Biosci 227:12–19PubMedCentralPubMedGoogle Scholar
  7. Stojilkovic SS, Tabak J, Bertram R (2010) Ion channels and signaling in the pituitary gland. Endocr Rev 31:845–915PubMedCentralPubMedGoogle Scholar
  8. Stravreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA, Pooley JR, Johnson TA, Voss TC, Lightman SL, Hager GL (2009) Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol 11:1093–1102Google Scholar
  9. Walker JJ, Terry JR, Lightman SL (2010) Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis. Proc R Soc B 277:1627–1633PubMedCentralPubMedGoogle Scholar
  10. Windle RJ, Wood SA, Shanks N, Lightman SL, Ingram CD (1998) Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress. Endocrinology 139:443–450PubMedGoogle Scholar

Further Reading

  1. Freeman ME, Kanyicska B, Lerant A, Nagy G (2000) Prolactin: structure, function, and regulation of secretion. Physiol Rev 80:1523–1631PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of MathematicsFlorida State UniversityTallahasseeUSA