Endocrine Cell Function and Dysfunction
The endocrine system refers to the cells and tissue that release hormones into the blood. Unlike synaptic chemical communication, which is localized to the target cell, endocrine communication is global. The hormones act on other endocrine glands such as the adrenal gland, ovaries, testes, and others, as well as on the heart, kidneys, muscle, and the brain. Mathematical modeling has been used to understand network interactions mediated by the endocrine system, as well as the effects of hormones on single cells.
Like neurons, many endocrine cells are electrically excitable and release hormones through Ca2+-mediated exocytosis (Stojilkovic et al. 2010). These have been the focus of mathematical modeling and computer simulation to better understand the mechanisms through which the cells operate. Several endocrine cell types are involved in diseases with substantial morbidity and mortality, making them an important target for model-assisted...
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