Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Intraspinal Stimulation

  • Michel Lemay
  • Simon F. Giszter
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_594

Synonyms

Definition

Intraspinal stimulation or microstimulation generally refers to electrical activation of the spinal cord through delivery of electrical current directly into the spinal tissue using microwire electrodes implanted into the white or grey matter of the cord. The term may also be applied for activation of the spinal tissue through iontophoresis (Saltiel et al. 1998) or optogenetics method (Alilain and Silver 2009). The range of applications includes lower and upper limb movements, bladder and bowel function, and respiration.

Detailed Description

The Spinal Solution to Multi-joint Movement Control and Other Problems

As evidenced in other sections of this encyclopedia (“ Vertebrate Pattern Generation: Overview”), part of the substantial repertoire of movements observed in vertebrates is programmed at the level of the spinal cord and can function after injury to more rostral levels. Thus, “One...

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References

  1. Alilain WJ, Li X, Horn KP, Dhingra R, Dick TE, Herlitze S, Silver J (2008) Light-induced rescue of breathing after spinal cord injury. J Neurosci 28:11862–11870PubMedCentralPubMedGoogle Scholar
  2. Alilain WJ, Silver J (2009) Shedding light on restoring respiratory function after spinal cord injury. Front Mol Neurosci 2:18PubMedCentralPubMedGoogle Scholar
  3. Andrews BJ, Baxendale RH, Barnett R, Phillips GF, Yamazaki T, Paul JP, Freeman PA (1988) Hybrid FES orthosis incorporating closed loop control and sensory feedback. J Biomed Eng 10:83–93Google Scholar
  4. Barthelemy D, Leblond H, Provencher J, Rossignol S (2006) Nonlocomotor and locomotor hindlimb responses evoked by electrical microstimulation of the lumbar cord in spinalized cats. J Neurophysiol 96:3273–3292PubMedGoogle Scholar
  5. Berniker M, Jarc A, Bizzi E, Tresch MC (2009) Simplified and effective motor control based on muscle synergies to exploit musculoskeletal dynamics. Proc Natl Acad Sci USA 106:7601–7606PubMedCentralPubMedGoogle Scholar
  6. Boyce VS, Lemay MA (2009) Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin-treated chronic spinal cats. J Neurophysiol 101:1309–1320PubMedCentralPubMedGoogle Scholar
  7. Burke RE (1992) Movement programs in the spinal cord (commentary). Behav Brain Sci 15:722Google Scholar
  8. Chizeck HJ, Kobetic R, Marsolais EB, Abbas JJ, Donner IH, Simon E (1988) Control of functional neuromuscular stimulation system for standing and locomotion in paraplegics. Proc IEEE 76:1155–1165Google Scholar
  9. de Groat WC, Wickens C (2013) Organization of the neural switching circuitry underlying reflex micturition. Acta Physiol (Oxf) 207:66–84Google Scholar
  10. Gaunt RA, Prochazka A (2006) Control of urinary bladder function with devices: successes and failures. Prog Brain Res 152:163–194PubMedGoogle Scholar
  11. Gaunt RA, Prochazka A, Mushahwar VK, Guevremont L, Ellaway PH (2006) Intraspinal microstimulation excites multisegmental sensory afferents at lower stimulus levels than local alpha-motoneuron responses. J Neurophysiol 96:2995–3005PubMedGoogle Scholar
  12. Giszter SF, Kargo WJ (2001) Modeling of dynamic controls in the frog wiping reflex: force-field level controls. Neurocomputing 38–40:1239–1247Google Scholar
  13. Giszter SF, Mussa-Ivaldi FA, Bizzi E (1993) Convergent force fields organized in the frog's spinal cord. J Neurosci 13:467–491PubMedGoogle Scholar
  14. Giszter SF, Moxon KA, Rybak I, Chapin JK (2000) A neurobiological perspective on humanoid robot design. IEEE Intell Syst 14:64–69Google Scholar
  15. Grill JH, Peckham PH (1998) Functional neuromuscular stimulation for combined control of elbow extension and hand grasp in C5 and C6 quadriplegics. IEEE Trans Rehabil Eng 6:190–199PubMedGoogle Scholar
  16. Grill WM, Bhadra N, Wang B (1999) Bladder and urethral pressures evoked by microstimulation of the sacral spinal cord in cats. Brain Res 836:19–30PubMedGoogle Scholar
  17. Guevremont L, Renzi CG, Norton JA, Kowalczewski J, Saigal R, Mushahwar VK (2006) Locomotor-related networks in the lumbosacral enlargement of the adult spinal cat: activation through intraspinal microstimulation. IEEE Trans Neural Syst Rehabil Eng 14:266–272PubMedGoogle Scholar
  18. Gustafsson B, Jankowska E (1976) Direct and indirect activation of nerve cells by electrical pulses applied extracellularly. J Physiol (Lond) 258:33–61PubMedCentralGoogle Scholar
  19. Handa Y, Handa T, Ichie M, Murakami H, Hoshimiya N, Ishikawa S, Ohkubo K (1992) Functional Electrical Stimulation (FES) systems for restoration of motor function of paralyzed muscles – versatile systems and a portable system. Front Med Biol Eng 4:241–255PubMedGoogle Scholar
  20. Hincapie JG, Kirsch RF (2009) Feasibility of EMG-based neural network controller for an upper extremity neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng 17:80–90PubMedCentralPubMedGoogle Scholar
  21. Hincapie JG, Blana D, Chadwick EK, Kirsch RF (2008) Musculoskeletal model-guided, customizable selection of shoulder and elbow muscles for a C5 SCI neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng 16:255–263PubMedCentralPubMedGoogle Scholar
  22. Keith MW, Kilgore KL, Peckham PH, Wuolle KS, Creasey G, Lemay M (1996) Tendon transfers and functional electrical stimulation for restoration of hand function in spinal cord injury. J Hand Surg [Am] 21:89–99Google Scholar
  23. Kralj A, Bajd T, Turk R, Krajnik J, Benko H (1983) Gait restoration in paraplegic patients: a feasibility study using multichannel surface electrodes FES. J Rehabil R&D 20:3–20Google Scholar
  24. Lane MA, Lee KZ, Fuller DD, Reier PJ (2009) Spinal circuitry and respiratory recovery following spinal cord injury. Respir Physiol Neurobiol 169:123–132PubMedCentralPubMedGoogle Scholar
  25. Lemay MA, Crago PE (1997) Closed-loop wrist stabilization in C4 and C5 tetraplegia. IEEE Trans Rehabil Eng 5:244–252PubMedGoogle Scholar
  26. Lemay MA, Grill WM (2004) Modularity of motor output evoked by intraspinal microstimulation in cats. J Neurophysiol 91:502–514PubMedGoogle Scholar
  27. Lemay MA, Grasse D, Grill WM (2009) Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats. IEEE Trans Neural Syst Rehabil Eng 17:379–389PubMedCentralPubMedGoogle Scholar
  28. Marsolais BE, Kobetic R, Chizeck HJ, Jacobs JL (1991) Orthoses and electrical stimulation for walking in complete paraplegia. J Neurol Rehabil 5:13–22Google Scholar
  29. Moritz CT, Lucas TH, Perlmutter SI, Fetz EE (2007) Forelimb movements and muscle responses evoked by microstimulation of cervical spinal cord in sedated monkeys. J Neurophysiol 97:110–120PubMedGoogle Scholar
  30. Mushahwar VK, Horch KW (1997) Proposed specifications for a lumbar spinal cord electrode array for control of lower extremities in paraplegia. IEEE Trans Rehabil Eng 5:237–243PubMedGoogle Scholar
  31. Mushahwar VK, Horch KW (2000a) Muscle recruitment through electrical stimulation of the lumbo-sacral spinal cord. IEEE Trans Rehabil Eng 8:22–29PubMedGoogle Scholar
  32. Mushahwar VK, Horch KW (2000b) Selective activation of muscle groups in the feline hindlimb through electrical microstimulation of the ventral lumbo-sacral spinal cord. IEEE Trans Rehabil Eng 8:11–21PubMedGoogle Scholar
  33. Mussa-Ivaldi FA (1997) Nonlinear force fields: a distributed system of control primitives for representing and learning movements. In: 1997 I.E. international symposium on computational intelligence in robotics and automation, Monterey, pp 84–90Google Scholar
  34. Nashold BS Jr, Friedman H, Grimes J (1981) Electrical stimulation of the conus medullaris to control the bladder in the paraplegic patient. A 10-year review. Appl Neurophysiol 44:225–232PubMedGoogle Scholar
  35. Nathan RH, Ohry A (1990) Upper limb functions regained in quadriplegia: a hybrid computerized neuromuscular stimulation system. Arch Phys Med Rehabil 71:415–421PubMedGoogle Scholar
  36. Pikov V, Bullara L, McCreery DB (2007) Intraspinal stimulation for bladder voiding in cats before and after chronic spinal cord injury. J Neural Eng 4:356–368PubMedCentralPubMedGoogle Scholar
  37. Saigal R, Renzi C, Mushahwar VK (2004) Intraspinal microstimulation generates functional movements after spinal-cord injury. IEEE Trans Neural Syst Rehabil Eng 12:430–440PubMedGoogle Scholar
  38. Saltiel P, Tresch MC, Bizzi E (1998) Spinal cord modular organization and rhythm generation: an NMDA iontophoretic study in the frog. J Neurophysiol 80:2323–2339PubMedGoogle Scholar
  39. Smith BT, Mulcahey MJ, Betz RR (1996) Development of an upper extremity FES system for individuals with C4 tetraplegia. IEEE Trans Rehabil Eng 4:264–270PubMedGoogle Scholar
  40. Tai C (2003) Multi-joint movement of the cat hindlimb evoked by microstimulation of the lumbosacral spinal cord. Exp Neurol 183:620–627PubMedGoogle Scholar
  41. Tai C, Booth AM, de Groat WC, Roppolo JR (2004) Bladder and urethral sphincter responses evoked by microstimulation of S2 sacral spinal cord in spinal cord intact and chronic spinal cord injured cats. Exp Neurol 190:171–183PubMedGoogle Scholar
  42. Tresch MC, Bizzi E (1999) Responses to spinal microstimulation in the chronically spinalized rat and their relationship to spinal systems activated by low threshold cutaneous stimulation. Exp Brain Res 129:401–416PubMedGoogle Scholar
  43. Zimmermann JB, Seki K, Jackson A (2011) Reanimating the arm and hand with intraspinal microstimulation. J Neural Eng 8:054001PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of BioengineeringTemple UniversityPhiladelphiaUSA
  2. 2.Neurobiology and AnatomyDrexel University College of Medicine and School of Biomedical Engineering and Health SystemsPhiladelphiaUSA