Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Epidural Stimulation

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_591

Synonyms

Definition

Epidural stimulation is the mode of electrical activation of neuronal structures by electrodes implanted in the epidural space. Theoretically, epidural electrodes can be placed anywhere overlying the dural mater of the nervous system, but they typically have been placed over the spinal cord or overlying the cortical region of the brain. Clinical application of epidural stimulation is connected with pain control, treatment of spasticity, and regulation of motor functions after neurological disorders. Another newly developed application of epidural stimulation is to facilitate improved sensory-motor function after paralysis as a result of spinal cord injury. A third application of epidural stimulation that is emerging is its use as a chronically implanted device to be used for a neurophysiological assessment of functional connectivity along specific descending...

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References

  1. Barolat G (2000) Spinal cord stimulation for chronic pain management. Arch Med Res 31:258–262PubMedGoogle Scholar
  2. Coburn B (1985) A theoretical study of epidural electrical stimulation of the spinal cord – part II. Effects on long myelinated fibers. IEEE Trans Biomed Eng 32:978–986PubMedGoogle Scholar
  3. Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR (2009) Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat Neurosci 12:1333–1342PubMedCentralPubMedGoogle Scholar
  4. Gerasimenko YP, Roy RR, Edgerton VR (2008) Epidural stimulation: comparison of the spinal circuits that generate and control locomotion in rats, cats and humans. Exp Neurol 209:417–425PubMedCentralPubMedGoogle Scholar
  5. Guan Y, Wacnik PW, Yang F, Carteret AF, Chung CY, Meyer RA, Raja SN (2010) Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats. Anesthesiology 113(6):1392–1405PubMedGoogle Scholar
  6. Harkema S, Gerasimenko Y, Hodes J, Burdick J, Angeli C, Chen Y, Ferreira C, Willhite A, Rejc E, Grossman RG, Edgerton VR (2011) Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet 377:1938–1947PubMedCentralPubMedGoogle Scholar
  7. Holsheimer J (2002) Which neuronal elements are activated directly by spinal cord stimulation. Neuromodulation 5:25–31PubMedGoogle Scholar
  8. Iwahara T, Atsuta Y, Garcia-Rill E, Skinner R (1991) Spinal cord stimulation induced locomotion in adult cat. Brain Res Bull 28:99–105Google Scholar
  9. Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150:971–979PubMedGoogle Scholar
  10. Oakley JC, Prager JP (2002) Spinal cord stimulation: mechanisms of action. Spine 27(22):2574–2583PubMedGoogle Scholar
  11. Shah PK, Gerasimenko Y, Shyu A, Lavrov I, Zhong H, Roy RR, Edgerton VR (2012) Variability in step training enhances locomotor recovery after a spinal cord injury. Eur J Neurosci 36:2054–2062PubMedCentralPubMedGoogle Scholar
  12. Shealy CN, Mortimer JT, Resnick J (1967) Electrical inhibition of pain by stimulation of the dorsal columns: preliminary reports. J Int Anesth Res Soc 46:489–491Google Scholar
  13. Suner S, Fellows MR, Vargas-Irwin C, Nakata GK, Donoghue JP (2005) Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex. IEEE Trans Neural Syst Rehabil Eng 13(4):524–541PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Pavlov Institute of PhysiologySt. PetersburgRussia
  2. 2.Department of Integrative Biology and Physiology, and Brain Research InstituteUniversity of CaliforniaLos AngelesUSA