Extracellular Potentials, Forward Modeling of
Forward modeling of extracellular potentials refers to the calculation of electrical potentials recorded inside or outside the brain due to activity in neuronal (and, if relevant, glial) sources. This contrasts the “inverse” problem which amounts to estimating the underlying neural sources from recorded potentials.
Extracellular potentials recorded inside or outside the brain are generated by transmembrane currents from cells in the vicinity of the recording electrode. To propagate from the membrane to a recording electrode inside the brain, the signal has to pass through brain tissue consisting of a tightly packed matrix of neurons and glial cells embedded in the extracellular medium (Nunez and Srinivasan 2006). A well-founded biophysical forward-modeling scheme (Rall and Shepherd 1968; Holt and Koch 1999), incorporating detailed...
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