Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Epilepsy, Neural Population Models of

  • Fabrice Wendling
  • Behnam Molaee-Ardekani
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_58


Epilepsy is a set of neurological disorders and syndromes characterized by recurrent seizures. Neural Population Models can serve as biomathematical representation of an abnormal neuronal assembly by altering parameters to reproduce epileptiform activity. Typically, parameters related to excitatory or inhibitory synaptic transmission can be modified (with respect to physiological values) to generate events that match those actually observed in local field potentials or in the EEG during ictal (seizures) or interictal (outside seizures) periods.

Detailed Description

Epilepsy is a pathological condition in which the nature of the interactions between neurons and the properties of neurons themselves are altered. These alterations lead to the development of epileptogenic networks in the brain over which transitions from normal to epileptic activity can spontaneously occur. Epileptogenic networks consists in extended networks of neurons characterized by abnormal synchronization...

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.INSERM, U1099RennesFrance
  2. 2.University of Rennes 1, LTSIRennesFrance
  3. 3.Clinical Neurophysiology DepartmentSalengro Hospital, University of Lille 2LilleFrance
  4. 4.CHRU Salengro Hospital (Clinical Neurophysiology Center)LilleFrance