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Encyclopedia of Computational Neuroscience pp 2720–2723Cite as

Slow Oscillations: Models

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Synonyms

Up and down state models

Definition

Several computational models have been proposed to describe the generation of spontaneous slow oscillations, or up and down state dynamics, in neuronal circuits of the cerebral cortex. Most models rely on strong excitatory feedback to generate reverberatory dynamics in the up state, which are then quenched by some negative feedback mechanism to form down states. The specific mechanisms responsible for triggering the transitions between up and down states distinguish these models. In addition, some models have been proposed that emphasize the role of thalamocortical loops in generating this spontaneous activity.

Detailed Description

During non-REM sleep and under most anesthetics, cortical network dynamics exhibit slow oscillations or up and down state switching (see Slow Oscillations: Physiology). This pattern of activity has been the subject of numerous computational models, which have formulated quantitative accounts of the possible...

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References

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Author information

Authors and Affiliations

  1. Systems Neuroscience, IDIBAPS, Barcelona, Spain

    Albert Compte

Authors
  1. Albert Compte
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Corresponding author

Correspondence to Albert Compte .

Editor information

Editors and Affiliations

  1. Department of Biology, Emory University, Atlanta, GA, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, FL, USA

    Ranu Jung

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Compte, A. (2015). Slow Oscillations: Models. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6675-8_307

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