Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Imaging, Electron Microscopy

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_282

Synonyms

Definition

Electron microscopy is the method by which electrons interact with a sample and are collected to detect a signal or change in sample density. This density is then either transferred onto a photographic plate or digitally recorded to create an electron micrograph.

Detailed Description

Electron microscopy is an imaging technique used by those who require a higher resolution than conventional light microscopy allows. Electrons are emitted from a filament tip and are accelerated and focused into a beam that targets and interacts with a sample. Electrons are then collected, and an image is recorded based on the results of those interactions.

Applications

Electron microscopy is often applied to samples of either biological origins or inorganic materials, including metals and crystals. Biological specimens include microorganisms, fixed tissue samples, and small structures, ranging down to large molecules or proteins.

Elect...

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References

  1. Ruska E (1986) Ernst Ruska autobiography. Nobel Foundation, StockholmGoogle Scholar
  2. Williams D, Carter CB (1996) The Transmission Electron Microscope. Springer.Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Biomedical OpticsMax-Planck Institute for Medical ResearchHeidelbergGermany