Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Extracellular Signal-Regulated Kinases, Models of

  • Susana R. Neves
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_188



Mitogen-activated protein (MAP) kinases consist of a family of protein kinases activated by a variety of cellular stimuli (Pearson et al. 2001). Four subfamilies of mammalian MAPK have been identified: ERK1 and ERK2: JNK; p38; and ERK5. Extracellular regulated kinase 1 and 2 (ERK1, ERK2), the original MAPK, was discovered as a kinase activity regulated by insulin. For a historical perspective on the discovery of the ERK cascade, see Blenis (1993). ERK1 and ERK2 (also known as p44 and p42 MAPK) signaling is key for the induction of synaptic plasticity and is essential for learning and memory (Thomas and Huganir 2004).

Detailed Description

The core ERK signaling module consists of a three-tiered kinase cascade: the MAPKKK Raf1 or B-Raf that phosphorylates and activates the MAPKK MEK1/2 that in turn phosphorylates and activates the MAPK ERK1/2. The small G protein Ras activates Raf, the first kinase in the cascade. Activation of...

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Pharmacology and Systems TherapeuticsFriedman Brain Institute, Icahn School of Medicine at Mount SinaiNew YorkUSA