Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Excitability: Types I, II, and III

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_151

Definition

In 1948, Hodgkin distinguished between three classes of excitability on the basis of spiking patterns observed in crustacean axons. This classification scheme is still applied today because it captures fundamental differences in excitability that stem from how action potentials, or spikes, are generated. The nonlinear dynamical mechanism responsible for spike initiation in each cell class has been worked out, and the biophysical implementation of those dynamical mechanisms is reasonably well understood. Moreover, the differences in spike initiation that define each class confer differences in metrics like the phase-response curve (PRC) and spike-triggered average (STA), meaning that this simple classification scheme is predictive of important differences in neural coding.

Detailed Description

Historical Background

Based on single fiber recordings from the crab Carcinus maenas, Hodgkin ( 1948) identified three different classes of excitability. Class 1 axons were capable of...
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References

  1. Ermentrout GB, Galan RF, Urban NN (2007) Relating neural dynamics to neural coding. Phys Rev Lett 99:248103PubMedCentralPubMedGoogle Scholar
  2. Hodgkin AL (1948) The local electric changes associated with repetitive action in a non-medullated axon. J Physiol 107:165–181PubMedCentralPubMedGoogle Scholar
  3. Izhikevich EM (2007) Dynamical systems in neuroscience. MIT Press, Cambridge, MAGoogle Scholar
  4. Prescott SA, De Koninck Y, Sejnowski TJ (2008) Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput Biol 4:e1000198PubMedCentralPubMedGoogle Scholar
  5. Ratté S, Hong S, De Schutter E, Prescott SA (2013) Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer. Neuron 78:758–772PubMedCentralPubMedGoogle Scholar
  6. Rinzel J, Ermentrout B (1989) Analysis of neural excitability and oscillations. In: Koch C, Segev I (eds) Methods in neuronal modeling. MIT Press, Cambridge, MAGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Neurosciences and Mental HealthThe Hospital for Sick ChildrenTorontoCanada