Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Inward Rectifier Potassium Channels

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_129

Synonyms

Definition

Inward rectifier potassium channels, also called Kir channels are potassium channels which, on the contrary of the other potassium channels, let little potassium ions flow outside of the cell and allow a large inflow of potassium ions inside the cells. In other words, inward rectifier currents present a reduced outward current at membrane potential above the potassium reversal potential and large inward current for membrane potential below the potassium reversal potential.

Detailed Description

First described in skeletal muscle, these channels have been identified in several other cell types: cardiac myocytes, blood cells, osteoclasts, endothelial cells, epithelial cells, oocytes, neurons, and glial cells (for review, see Hibino et al. 2010).

The inward rectifier potassium channels are part of a heterogeneous family of potassium channels named Kir m.n or KCNJ.x. This family can...

This is a preview of subscription content, log in to check access.

References

  1. Derjean D, Bertrand S, Le Masson G, Landry M, Morisset V, Nagy F (2003) Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states. Nat Neurosci 6(3):274–281PubMedGoogle Scholar
  2. Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095–1114PubMedGoogle Scholar
  3. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y (2010) Inwardly rectifying potassium channels: their structure, function and physiological roles. Physiol Rev 90(1):291–366PubMedGoogle Scholar
  4. Hille B (2001) Ion channels of excitable membrane, 3rd edn. Sinauer Associates, SunderlandGoogle Scholar
  5. Le Franc Y, Le Masson G (2010) Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. J Neurophysiol 104(4):1978–1996PubMedGoogle Scholar
  6. Lüscher C, Slesinger PA (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci 11(5):301–315PubMedCentralPubMedGoogle Scholar
  7. Sanders H, Berends M, Major G, Goldman MS, Lisman JE (2013) NMDA and GABAB(KIR) conductances: the “perfect couple” for bistability. J Neurosci 33(2):424–429PubMedCentralPubMedGoogle Scholar
  8. Wang J, Huang Y, Ning Q (2011) Review on regulation of inwardly rectifying potassium channels. Crit Rev Eukaryot Gene Expr 21(4):303–311PubMedGoogle Scholar
  9. Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marant M, O’Donnel P, Finkel LH (2005) NMDA-AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080–9095PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Theoretical Neurobiology and NeuroengineeringUniversity of AntwerpWilrijkBelgium