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Anti-B7-H4

Living reference work entry

Abstract

B7-H4, also known as B7x or B7S1, is a new member of the B7 family of immune co-signaling molecules. Despite the wide distribution in mRNA levels, B7-H4 protein expression is generally absent in peripheral tissues but is increased on many cancer cells or tumor-associated immune cells. In addition, B7-H4 up-regulation has shown to be associated with diseases progression and/or outcome in some cancers. The unique expression of B7-H4 in the tumor microenvironment and its potential immune inhibitory functions on both innate and adaptive immune responses represents a novel target for the next-generation cancer diagnosis and immunotherapy.

Keywords

B7 homolog 4 (B7-H4) Antigen-dependent induction Downstream gene target of p70S6K ELISA Immunohistochemistry Cancer Marker for pancreatic ductal adenocarcinoma (PDA) Neutrophil progenitor cell proliferation Preclinical studies Shield for immunosurveillance evasion Soluble form Staining in tumor endothelial vasculature T-cell inhibition T regulatory cell trafficking Therapeutics for autoimmune diseases and islet transplantation B7S11–3. See B7 homolog 4 (B7-H4) B7x. See B7 homolog 4 (B7-H4) 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Immunobiology and Yale Cancer CenterYale University School of MedicineNew HavenUSA
  2. 2.Cancer Immunology ProgramYale University School of Medicine, Yale Cancer CenterNew HavenUSA

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