Encyclopedia of Behavioral Medicine

Living Edition
| Editors: Marc Gellman

Cellular Theory of Aging

  • Emil C. ToescuEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6439-6_447-2

Definition

Cellular theories explain the aging process as originating in individual cells, either at the level of the genetic information or through changes in metabolism.

Description

The quest for understanding the process of aging is probably as long as human history, and its resolution is still far from clear or even assured. A major factor for this state of affairs is that aging is a complex, multifactorial process that develops during ontogeny gradually, at multiple levels, involving a certain degree of stochastic randomness. At a certain time (early 1990s), more than 300 various hypotheses were circulating for explaining aging, and, responding to a need for organizing such a vast catalogue, these hypotheses were classified as cellular theories that explain the aging process as originating in individual cells, either at the level of the genetic information or through changes in metabolism; system theories, that propose that aging, while expressed at the level of individual cells,...

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References and Further Reading

  1. Bratic, I., & Trifunovic, A. (2010). Mitochondrial energy metabolism and ageing. Biochimica et Biophysica Acta, 1797(6–7), 961–967.CrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Medical SciencesThe University of BirminghamEdgbaston, BirminghamUK

Section editors and affiliations

  • Anna C. Whittaker
    • 1
  1. 1.School of Sport, Exercise and Rehabilitation SciencesUniversity of BirminghamBirminghamUK