Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

The 5-HT3 Receptor

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_647-1

Synonyms

Historical Background

5-Hydroxytryptamine (5-HT), also known as serotonin, was initially identified as a potent vasoconstrictor present in blood serum (Rapport et al. 1947), but it has become obvious over the years that 5-HT has a multitude of functions, including activation or inhibition of muscle, exocrine and endocrine glands, central and peripheral neurons, and cells of the hematopoietic and immune systems. 5-HT initiates its actions by binding to specific receptor proteins in the cell membrane. These 5-HT receptors were initially subdivided into D and M subtypes, based on their sensitivity to dibenyline or morphine (Gaddum and Picarelli 1957). This was an oversimplification, and currently 5-HT receptors are divided into seven major families (5-HT1–7) based on transduction and structural characteristics. All of these receptors exert their effects via G proteins, except for the 5-HT3receptor which is a ligand-gated ion channel (LGIC),...

Keywords

Single Channel Conductance Adjacent Subunit nACh Receptor Specific Receptor Protein GluCl Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of CambridgeCambridgeUK