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Encyclopedia of Signaling Molecules pp 1–7Cite as

ARAP3

  • Living reference work entry
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Synonyms

ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains containing protein 3; Centaurin delta 3; Centd3; Drag1; Expressed sequence AI851258

Historical Background

Small GTPases of the Ras superfamily are binary switches that, by cycling between active GTP-bound and inactive GDP-bound conformations, regulate a wide variety of cellular and developmental events. They are grouped based on the sequence homology and cellular functions into five families: Ras, Rho, Ran, Rab, and ARF. The Rho and ARF family small GTPases are well established as regulators of cellular actin rearrangements and vesicular trafficking (Bos et al. 2007). Small GTPases are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of small GTPase-bound GDP to GTP, whereas GTPase-activating proteins (GAPs) inactivate small GTPases by stimulating hydrolysis of the small GTPase-bound GTP to GDP (Bos et al. 2007). In general, each small GTPase family has its specific GEFs and...

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References

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Authors and Affiliations

  1. Institute of Life Science 1, School of Medicine, Swansea University, SA2 8PP, Swansea, Wales, UK

    Siân-Eleri Owens, Salman Tamaddon-Jahromi & Venkateswarlu Kanamarlapudi

Authors
  1. Siân-Eleri Owens
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  2. Salman Tamaddon-Jahromi
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  3. Venkateswarlu Kanamarlapudi
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Corresponding author

Correspondence to Venkateswarlu Kanamarlapudi .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Owens, SE., Tamaddon-Jahromi, S., Kanamarlapudi, V. (2016). ARAP3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_611-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_611-1

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  • Online ISBN: 978-1-4614-6438-9

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