Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Cdc7

  • Hisao Masai
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_593-1

Synonyms

Historical Background

Cdc7 was originally discovered as a temperature-sensitive mutant of budding yeast defective in progression of cell cycle (Hartwell 1973). The growth of cdc7(ts) is arrested immediately before the onset of the S phase at a nonpermissive temperature. Upon return to a permissive temperature, cells resume growth and can complete S phase in the absence of ongoing protein synthesis. This led to the notion that Cdc7 is required for DNA replication at the stage where all other proteins required for DNA synthesis are prepared. Cdc7 was later cloned and was identified as encoding a serine/threonine kinase (Hollingsworth and Sclafani 1990). Dbf4, another cell cycle regulator required at the onset of the S phase, was then shown to encode an activation subunit for Cdc7. An ortholog of Cdc7 was first identified in fission yeast (Hsk1; (Masai et al. 1995...

Keywords

Fission Yeast Replication Stress Sister Chromatid Cohesion Cdc7 Kinase Cdc7 Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Genome Dynamics Project, Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan