Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Pin1

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_581-1

Synonyms

Historical Background

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIn1) is a phosphorylation-dependent peptidyl-prolyl isomerase that was first isolated by a yeast two-hybrid screen designed to identify human proteins which interact with the product of the “never in mitosis” gene A (NIMA) (Lu et al. 1996). Sequence analysis revealed that human Pin1 exhibits approximately 45% amino acid sequence similarity with the product of the ESS1 gene that was previously identified as essential for growth in the budding yeast Saccharomyces cerevisiae (Hanes et al. 1989). It has subsequently been found that Pin1-like proteins are highly conserved and found in both eukaryotes and prokaryotes (Maruyama et al. 2004). While it initially implicated as a regulator of mitosis, it is evident that Pin1 has roles in a number of biological processes.

Pin1 is...

Keywords

Permeability Catalysis Serine Proline Lysine 
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References

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of BiochemistrySchulich School of Medicine & Dentistry, The University of Western OntarioLondonCanada
  2. 2.Department of OncologySchulich School of Medicine & Dentistry, The University of Western OntarioLondonCanada