References
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. J Biol Chem. 2000;275:33427–34.
de la Puerta ML, Trinidad AG, del Carmen RM, Bogetz J, Sanchez Crespo M, Mustelin T, et al. Characterization of new substrates targeted by Yersinia tyrosine phosphatase YopH. PLoS One. 2009;4:e4431.
Engelmann S, Togni M, Kliche S, Reinhold D, Schraven B, Reinhold A. The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis. Crit Rev Immunol. 2015;35:1–14.
Fiege JK, Burbach BJ, Shimizu Y. Negative regulation of memory phenotype CD8 T cell conversion by adhesion and degranulation-promoting adapter protein. J Immunol. 2015;195:3119–28.
Hamamy H, Makrythanasis P, Al-Allawi N, Muhsin AA, Antonarakis SE. Recessive Thrombocytopenia likely due to a Homozygous Pathogenic Variant in the FYBgene: case report. BMC Med Genet. 2014;15:135. doi:10.1186/s12881-014-0135-0.
Heuer K, Kofler M, Langdon G, Thiemke K, Freund C. Structure of a helically extended SH3 domain of the T cell adapter protein ADAP. Stucture. 2004;12:603–10.
Horn J, Wang X, Reichardt P, Stradal TE, Warnecke N, Simeoni L, et al. Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells. J Immunol. 2009;183:5756–67.
Jordan MS, Koretzky GA. Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76. Cold Spring Harb Perspect Biol. 2010;2(4):a002501.
Kasirer-Friede A, Ruggeri ZM, Shattil SJ. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010;115:2274–82.
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin alphaIIbbeta3 activation and stable fibrinogen binding. Blood. 2014;123:3156–65.
Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, et al. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol. 2006;26:7130–44.
Koga S, Yogo K, Yoshikawa K, Samori H, Goto M, Uchida T, Ishida N, Takeya T. Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro. J Biol Chem. 2005;280:31564–71.
Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, et al. Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed t cell migration. Mol Cell Proteomics. 2015;14:2961–72.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, et al. Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. J Thromb Haemost. 2015;13:1285–92.
Litvinov IV, Netchiporouk E, Cordeiro B, Dore MA, Moreau L, Pehr K, et al. The use of transcriptional profiling to improve personalized diagnosis and management of cutaneous t-cell lymphoma (CTCL). Clin Cancer Res. 2015;21:2820–9.
Medeiros RB, Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, Shimizu Y. Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1. Sci. 2007;316:754–8.
Menasche G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol. 2007;27:4070–81.
Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D. ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens. J leukoc Biol. 2017;101:407–19.
Patzak IM, Konigsberger S, Suzuki A, Mak TW, Kiefer F. HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion. Eur J Immunol. 2010;40:3220–5.
Peterson EJ. The TCR ADAPts to integrin-mediated cell adhesion. Immunol Rev. 2003;192:113–21.
Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, et al. T cell receptor “inside-out” pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity. 2010;32:541–56.
Srivastava R, Burbach BJ, Shimizu Y. NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J Biol Chem. 2010;285:11100–5.
Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, et al. Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells. PLoS One. 2010;5:e11708.
Wang H, Rudd CE. SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. Trends Cell Biol. 2008;18:486–93.
Witte A, Degen J, Baumgart K, Waldt N, Kuropka B, Freund C, et al. Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-kB signaling in T cells. J Clin Cell Immunol 2012; S12. doi:10.4172/2155-9899.S12-002
Zimmermann J, Kuhne R, Sylvester M, Freund C. Redox-regulated conformational changes in an SH3 domain. Biochemistry. 2007;46:6971–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media LLC
About this entry
Cite this entry
Kasirer-Friede, A. (2016). ADAP. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_577-1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6438-9_577-1
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-6438-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences