Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Integrin α1 (ITGA1)

  • Jyrki Heino
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_556-1


Historical Background

Integrin α1 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. α1β1 is one of the first integrins found, and it was originally described as T lymphocyte very late activation antigen-1 (VLA-1). Today the human integrin family is known to contain 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are connected to cytoskeletal filaments and also to multiple cellular signaling pathways (Hynes 2004).


Integrins are single-pass type I membrane glycoproteins. Integrin α1 subunit contains short intracellular domain, transmembrane anchor, and an extracellular part, composed of α1I, β-propeller, thigh, calf-1, and calf-2 domains (Fig. 1). Thus, α1 belongs to a subgroup of integrins that contain an αI domain (inserted domain that is often...


Alport Syndrome Collagen Receptor Basement Membrane Collagen Mesenchymal Stem Cell Population Human Integrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol. 2007;19:495–507.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Ben-Horin S, Bank I. The role of very late antigen-1 in immune-mediated inflammation. Clin Immunol. 2004;113:119–29.CrossRefPubMedGoogle Scholar
  3. Eble JA. Matrix biology meets toxinology. Matrix Biol. 2010;29:239–47.CrossRefPubMedGoogle Scholar
  4. Gardner H. Integrin α1β1. Adv Exp Med Biol. 2014;819:21–39.CrossRefPubMedGoogle Scholar
  5. Heino J. The collagen family members as cell adhesion proteins. Bioessays. 2007;29:1001–10.CrossRefPubMedGoogle Scholar
  6. Heino J. Cellular signaling by collagen-binding integrins. Adv Exp Med Biol. 2014;819:143–55.CrossRefPubMedGoogle Scholar
  7. Herr AB, Farndale RW. Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem. 2009;284:19781–5.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Hynes RO. The emergence of integrins: a personal and historical perspective. Matrix Biol. 2004;23:333–40.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Ivaska J, Heino J. Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu Rev Cell Dev Biol. 2011;27:291–320.CrossRefPubMedGoogle Scholar
  10. Johnson MS, Lu N, Denessiouk K, Heino J, Gullberg D. Integrins during evolution: evolutionary trees and model organisms. Biochim Biophys Acta. 1788;2009:779–89.Google Scholar
  11. Legate KR, Fässler R. Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci. 2009;122:187–98.CrossRefPubMedGoogle Scholar
  12. Leitinger B. Transmembrane collagen receptors. Annu Rev Cell Dev Biol. 2011;27:265–90.CrossRefPubMedGoogle Scholar
  13. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol. 2007;25:619–47.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Pozzi A, Voziyan PA, Hudson BG, Zent R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des. 2009;15:1318–33.CrossRefPubMedGoogle Scholar
  15. Zeltz C, Gullberg D. The integrin-collagen connection-a glue for tissue repair? J Cell Sci. 2016;129:653–64.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of TurkuTurkuFinland