Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Integrin α1 (ITGA1)

  • Jyrki Heino
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_556-1

Synonyms

Historical Background

Integrin α1 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. α1β1 is one of the first integrins found, and it was originally described as T lymphocyte very late activation antigen-1 (VLA-1). Today the human integrin family is known to contain 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are connected to cytoskeletal filaments and also to multiple cellular signaling pathways (Hynes 2004).

Structure

Integrins are single-pass type I membrane glycoproteins. Integrin α1 subunit contains short intracellular domain, transmembrane anchor, and an extracellular part, composed of α1I, β-propeller, thigh, calf-1, and calf-2 domains (Fig. 1). Thus, α1 belongs to a subgroup of integrins that contain an αI domain (inserted domain that is often...

Keywords

Alport Syndrome Collagen Receptor Basement Membrane Collagen Mesenchymal Stem Cell Population Human Integrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of TurkuTurkuFinland