Integrin α1 (ITGA1)
Integrin α1 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. α1β1 is one of the first integrins found, and it was originally described as T lymphocyte very late activation antigen-1 (VLA-1). Today the human integrin family is known to contain 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are connected to cytoskeletal filaments and also to multiple cellular signaling pathways (Hynes 2004).
KeywordsArthritis Osteoporosis Tyrosine Retina Arginine
- Johnson MS, Lu N, Denessiouk K, Heino J, Gullberg D. Integrins during evolution: evolutionary trees and model organisms. Biochim Biophys Acta. 1788;2009:779–89.Google Scholar