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Encyclopedia of Signaling Molecules pp 1–7Cite as

Icmt (Isoprenylcysteine Carboxyl Methyltransferase)

  • Living reference work entry
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Synonyms

HSTE14; MGC39955; MST098; MSTP098; PCCMT; PCMT; PPMT

Historical Background

Isoprenylcysteine carboxyl methyltransferase (Icmt) is the only known prenylcysteine protein-dependent methyltransferase and plays a critical role in the posttranslational modification of prenylated proteins (Bergo et al. 2000). The Icmt ortholog from Saccharomyces cerevisiae, STE14p, was the first prenylcysteine carboxyl methyltransferase to be cloned and sequenced, and it is considered the founding member of this eukaryote protein methyltransferase family (Anderson et al. 2005). STE14p was originally recognized in a screen of mutant yeast, deficient of STE14, which rendered the yeast sterile due to their failure to methylate the mating pheromone a-factor, a protein crucial for fertility. STE14p is a 26 kDa integral membrane protein with multiple transmembrane (TM)-spanning domains and is localized to the endoplasmic reticulum (ER) (Romano and Michaelis 2001). Human Icmt cDNA possess notable homology...

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References

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Authors and Affiliations

  1. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The Medical University of South Carolina, MUSC Campus, 29425, Charleston, SC, USA

    Kathryn M. Appleton & Yuri K. Peterson

  2. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA

    Ian Cushman & Yuri K. Peterson

Authors
  1. Kathryn M. Appleton
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  2. Ian Cushman
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  3. Yuri K. Peterson
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Corresponding author

Correspondence to Yuri K. Peterson .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Appleton, K.M., Cushman, I., Peterson, Y.K. (2016). Icmt (Isoprenylcysteine Carboxyl Methyltransferase). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_519-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_519-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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