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Encyclopedia of Signaling Molecules pp 1–9Cite as

Regulator of Calcineurin 1 (RCAN1)

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Synonyms

ADAPT78; Calcipressin1; CBP1; Down syndrome candidate region 1 (DSCR1); Down syndrome critical region 1 (DSCR1); MCIP1; Nebula; RCN-1; Sarah

Historical Background

Regulator of calcineurin 1 (RCAN1) was first isolated by Fuentes et al. in 1995 during a search for genes associated with clinical features of Down syndrome (e.g., mental retardation and congenital heart disease) (Fuentes et al. 1995). Coding sequences of RCAN1 were identified from the 21q22.1–q22.2 regions of human chromosome 21 by an Alu-splice PCR method. It was initially thought that RCAN1 was significantly associated with the Down syndrome phenotype (Fuentes et al. 1997b); thus RCAN1 was first designated Down syndrome critical region 1 (DSCR1). Future studies showed that the DSCR1 gene product is a calcineurin regulator, and the new name “regulator of calcineurin (RCAN)” was adopted to describe the gene function. Although RCAN1 is still referred to as DSCR1, ADAPT78, MCIP1, Calpressin1, RCN-1, Nebular, Sarah,...

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References

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Authors and Affiliations

  1. Department of Molecular Pathophysiology, Institute for Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, 211-8533, Japan

    Masakazu Fujiwara & Mohammad Ghazizadeh

Authors
  1. Masakazu Fujiwara
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  2. Mohammad Ghazizadeh
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Correspondence to Masakazu Fujiwara .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Fujiwara, M., Ghazizadeh, M. (2016). Regulator of Calcineurin 1 (RCAN1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_389-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_389-1

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