Drosophila frizzled (Dfz1) was originally identified as a causative gene for a mutant with disoriented cuticular hairs and was then cloned and characterized as a seven-transmembrane-type protein similar to G protein-coupled receptors (GPCRs) (Vinson and Adler 1987; Lagerström and Schiöth 2008). The phenotype of the Dfz1 mutant was the aberrant polarization of epithelial cells within the epithelial plane or the dysregulation of planar cell polarity (PCP). Drosophila mutants of dishevelled, Van Gogh (Vang or strabismus), prickle, diego, and starry night (flamingo) show phenotypes similar to the Dfz1 mutant. Dfz1, Dishevelled, Vang, Prickle, Diego and Starry night are characterized as core PCP components (Katoh 2005; Wu and Mlodzik 2009).
KeywordsSynovial Sarcoma Williams Syndrome Planar Cell Polarity Neural Tube Defect Frizzle Receptor
- ClinicalTrials.gov database. US National Institute of Health. https://clinicaltrials.gov. Accessed 28 Aug 2016.