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PP2C

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Metal-dependent protein phosphatase; PPM; Protein serine/threonine-phosphatase 2C

Historical Background

Protein phosphatase 2C (PP2C) was first defined as magnesium (or manganese)-dependent Ser/Thr-specific dephosphorylation activity in mammalian tissue extract (Cohen 1989). This activity was also found to be resistant to okadaic acid, a potent inhibitor of Ser/Thr phosphatases. Because of its cation dependency, PP2C is sometimes referred as PPM (protein phosphatase, magnesium or manganese dependent). Genes encoding PP2C were subsequently isolated from yeast to humans, revealing a conserved protein phosphatase family with no apparent sequence similarity to the other Ser/Thr phosphatases such as PP1, PP2A, and PP2B. It is also notable that eukaryotic species have more genes encoding for PP2C than those for the other Ser/Thr phosphatase families. For example, the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombehave seven and six PP2C or...

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Authors and Affiliations

  1. Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630-0192, Japan

    Hisashi Tatebe & Kazuhiro Shiozaki

  2. Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, 95616, USA

    Kazuhiro Shiozaki

Authors
  1. Hisashi Tatebe
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  2. Kazuhiro Shiozaki
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Corresponding author

Correspondence to Kazuhiro Shiozaki .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Tatebe, H., Shiozaki, K. (2017). PP2C. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_249-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_249-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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