Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

HB-EGF (Heparin-Binding EGF-Like Growth Factor)

  • Ryo Iwamoto
  • Eisuke Mekada
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_127-1

Synonyms

Historical Background

Since the discovery of epidermal growth factor (EGF) in 1962, a total of seven mammalian ligands that bind the EGF receptor (EGFR/ErbB1) have been identified, including transforming growth factor-α (TGFα), amphiregulin (ARG), betacellulin (BTC), epiregulin (ERG), epigen (EPG), and heparin-binding EGF-like growth factor (HB-EGF) (Harris et al. 2003). Historically, HB-EGF was the fourth growth factor to be identified among EGFR-ligands. Major findings regarding HB-EGF are:
  • Discovery of HB-EGF (Higashiyama et al. 1991)

  • Identification of HB-EGF as the diphtheria toxin receptor (DTR) (Naglich et al. 1992; Iwamoto et al. 1994)

  • Identification of HB-EGF’s major role in EGFR transactivation (Prenzel et al. 1999)

  • Establishment of HB-EGF-null mouse lines (Iwamoto et al. 2003; Jackson et al. 2003)

  • Proof of the physiological significance of HB-EGF shedding...

Keywords

Rapidly Progressive Glomerulonephritis EGFR Activation Epidermal Growth Factor Family EGFR Ligand Diphtheria Toxin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Cell Biology, Research Institute for Microbial DiseasesOsaka UniversitySuita, OsakaJapan