Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

SLC34

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101997-1

Synonyms

Historical Background

Phosphorus is one of the six essential elements for life. Molecules containing anionic phosphate (PO43−) are constituents of genetic material (DNA, RNA) and are an essential building block of phospholipid membranes, bones, and teeth; high-energy phosphate bonds drive cell energetics via ATP/ADP hydrolysis; phosphorylation/dephosphorylation reactions are key events in intracellular signaling, and phosphate acts as an intra- and extracellular pH buffer. In mammals, phosphate is obtained from the diet in the form of inorganic phosphate (Pi) that exists in solution as negatively charged mono- (H2PO4) and divalent (HPO42−) ions in the physiological pH range. As such Pimust be actively transported “uphill” across the cell membrane from the external medium against its...

Keywords

Testicular Microlithiasis Transport Cycle SLC34 Transporter SLC34 Protein Hereditary Hypophosphatemic Rickets With Hypercalciuria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Florey Institute for Neuroscience and Mental HealthParkvilleAustralia
  2. 2.Institute for Cell and Molecular BiosciencesUniversity of Newcastle upon TyneNewcastle upon TyneUK