Phosphorus is one of the six essential elements for life. Molecules containing anionic phosphate (PO43−) are constituents of genetic material (DNA, RNA) and are an essential building block of phospholipid membranes, bones, and teeth; high-energy phosphate bonds drive cell energetics via ATP/ADP hydrolysis; phosphorylation/dephosphorylation reactions are key events in intracellular signaling, and phosphate acts as an intra- and extracellular pH buffer. In mammals, phosphate is obtained from the diet in the form of inorganic phosphate (Pi) that exists in solution as negatively charged mono- (H2PO4−) and divalent (HPO42−) ions in the physiological pH range. As such Pimust be actively transported “uphill” across the cell membrane from the external medium against its...
KeywordsTesticular Microlithiasis Transport Cycle SLC34 Transporter SLC34 Protein Hereditary Hypophosphatemic Rickets With Hypercalciuria
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