Historical Background
The natriuretic system constitutes a family of cardiac- and vascular-derived hormones named Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP), C-type Natriuretic Peptide (CNP), and Urodilatin (URO), which play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. Binding of natriuretic peptides (NPs) to either Natriuretic Peptide Receptor Type A (NPRA) or type B (NPRB) leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade, mediating most of the biological actions of these peptides (Anand-Srivastava and Trachte 1993). NPs bind also to NPRC, which is considered a clearance receptor responsible for receptor-mediated degradation of these peptides. In addition, recent studies have revealed multiple...
References
Anand-Srivastava MB. Natriuretic peptide receptor-C signaling and regulation. Peptides. 2005;26(6):1044–59.
Anand-Srivastava MB, Trachte GJ. Atrial natriuretic factor receptors and signal transduction mechanisms. Pharmacol Rev. 1993;45(4):455–97.
Bianciotti LG, Vatta MS, Elverdin JC, di Carlo MB, Negri G, Fernandez BE. Atrial natriuretic factor-induced amylase output in the rat parotid gland appears to be mediated by the inositol phosphate pathway. Biochem Biophys Res Commun. 1998;247(1):123–8.
Cantú SM, Donoso AS, Kouyoumdzian NM, Rukavina Mikusic NL, Puyó AM, et al. Clinical aspects of C-type natriuretic peptide on the cardiovascular system. Int J Clin Endocrinol Metab. 2015;1(2):031–6.
Cohen D, Cohen D, Koh GY, Nikonova LN, Porter JG, Maack T. Molecular determinants of the clearance function of type C receptors of natriuretic peptides. J Biol Chem. 1996;271(16):9863–9.
Collins S. A heart-adipose tissue connection in the regulation of energy metabolism. Nat Rev Endocrinol. 2014;10(3):157–63.
Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, et al. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009;110(4):738–47.
Hirata M, Chang CH, Murad F. Stimulatory effects of atrial natriuretic factor on phosphoinositide hydrolysis in cultured bovine aortic smooth muscle cells. Biochim Biophys Acta. 1989;1010:346–51.
Hu Q, Liu Q, Wang S, Zhen X, Zhang Z, Lv R, et al. NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study. Oncotarget. 2016;7(23):33662–74.
Jaubert F, Martin N, Washburn LL, Lee BK, Eicher EM, Guénet JL. Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3). Proc Natl Acad Sci U S A. 1999;96(18):10278–83.
Li Y, Hashim S, Anand-Srivastava MB. Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqα/MAP kinase signaling pathways. Cardiovasc Res. 2006;72:464–72.
Mouawad R, Li Y, Anand-Srivastava MB. Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells. Mol Pharmacol. 2004;65(4):917–24.
Murthy KS, Teng B, Jin J, Makhlouf GM. G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor. Am J Phys. 1998;275(6 Pt 1):pC1409–16.
Nagase M, Ando K, Katafuchi T, Kato A, Hirose S, Fujita T. Role of natriuretic peptide receptor type C in Dahl saltsensitive hypertensive rats. Hypertension. 1997;30(2 Pt 1):177–83.
Naruko T, Itoh A, Haze K, Ehara S, Fukushima H, Sugama Y, et al. C-type natriuretic peptide and natriuretic peptide receptors are expressed by smooth muscle cells in the neointima after percutaneous coronary intervention. Atherosclerosis. 2005;181:241–50.
Nussenzveig DR, Lewicki JA, Maack T. Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor. J Biol Chem. 1990;265(34):20952–8.
Prins BA, Weber MJ, Hu RM, Pedram A, Daniels M, Levin ER. Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor. Potential role in the inhibition of astrocyte proliferation. J Biol Chem. 1996;271(24):14156–62.
Rahmutula D, Nakayama T, Soma M, Kosuge K, Aoi N, Izumi Y, et al. Structure and polymorphisms of the human natriuretic peptide receptor C gene. Endocrine. 2002;17(2):85–90.
Rose RA, Giles WR. Natriuretic peptide C receptor signalling in the heart and vasculature. J Physiol. 2008;586(2):353–66.
Rubattu S, Sciarretta S, Morriello A, Calvieri C, Battistoni A, Volpe M. NPR-C: a component of the natriuretic peptide family with implications in human diseases. J Mol Med. 2010;88(9):889–97.
Rukavina Mikusic NL, Kravetz MC, Kouyoumdzian NM, Della Penna SL, Rosón MI, Fernández BE, et al. Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system. J Signal Transduct. 2014;2014:731350.
Sabbatini ME, Rodríguez M, di Carlo MB, Davio CA, Vatta MS, Bianciotti LG. C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas. Am J Physiol Gastrointest Liver Physiol. 2007;293(5):G987–94.
Saulnier PJ, Roussel R, Halimi JM, Lebrec J, Dardari D, Maimaitiming S, et al. Impact of natriuretic peptide clearance receptor (NPR3) gene variants on blood pressure in type 2 diabetes. Diabetes Care. 2011;34(5):1199–204.
Sun JZ, Oparil S, Lucchesi P, Thompson JA, Chen YF. Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells. Am J Phys Lung Cell Mol Phys. 2001;281(1):L155–63.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media LLC
About this entry
Cite this entry
Kouyoumdzian, N.M., Mikusic, N.L.R., Lee, H.J., Fernández, B.E., Choi, M.R. (2016). Natriuretic Peptide Receptor Type C (NPRC). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101995-1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101995-1
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6438-9
Online ISBN: 978-1-4614-6438-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences