Natriuretic Peptide Receptor Type C (NPRC)
The natriuretic system constitutes a family of cardiac- and vascular-derived hormones named Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP), C-type Natriuretic Peptide (CNP), and Urodilatin (URO), which play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. Binding of natriuretic peptides (NPs) to either Natriuretic Peptide Receptor Type A (NPRA) or type B (NPRB) leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade, mediating most of the biological actions of these peptides (Anand-Srivastava and Trachte 1993). NPs bind also to NPRC, which is considered a clearance receptor responsible for receptor-mediated degradation of these peptides. In addition, recent studies have revealed multiple...
KeywordsVascular Smooth Muscle Cell Brain Natriuretic Peptide Atrial Natriuretic Peptide Cardiac Fibroblast Atrial Natriuretic Peptide Level
- Cantú SM, Donoso AS, Kouyoumdzian NM, Rukavina Mikusic NL, Puyó AM, et al. Clinical aspects of C-type natriuretic peptide on the cardiovascular system. Int J Clin Endocrinol Metab. 2015;1(2):031–6.Google Scholar
- Murthy KS, Teng B, Jin J, Makhlouf GM. G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor. Am J Phys. 1998;275(6 Pt 1):pC1409–16.Google Scholar
- Sun JZ, Oparil S, Lucchesi P, Thompson JA, Chen YF. Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells. Am J Phys Lung Cell Mol Phys. 2001;281(1):L155–63.Google Scholar