Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • Avik Choudhuri
  • Anirban Ray
  • Arunima Biswas
  • Umadas MaitraEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101984-1


Historical Background

The Process of Translation Initiation

Translation initiation in eukaryotic cells is defined as the process by which a 40S ribosomal subunit containing bound initiator Met-tRNAi (methionine is the first N-terminal amino acid of all synthesized protein chains) interacts with an mRNA and selects the start AUG codon to set the reading frame of protein synthesis. The process involves the formation of multiple noncovalent intermediate biochemical complexes in a series of distinct partial steps and requires the essential participation of a dozen protein factors, collectively called the eukaryotic translation Initiation Factors (eIFs). A schematic representation of the canonical pathway of translation initiation from a translationally competent eukaryotic capped-mRNA is depicted in Fig. 1.
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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Avik Choudhuri
    • 1
  • Anirban Ray
    • 2
  • Arunima Biswas
    • 3
  • Umadas Maitra
    • 4
    Email author
  1. 1.Department of Stem Cell and Regenerative BiologyHarvard UniversityCambridgeUSA
  2. 2.Amity Institute of BiotechnologyAmity UniversityKolkataIndia
  3. 3.Department of MicrobiologyRaidighi CollegeRaidighi, South 24 ParganasIndia
  4. 4.Department of Developmental & Molecular BiologyAlbert Einstein College of MedicineBronx, New YorkUSA