Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

ACT

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101971-1

Synonyms

ACT

Historical Background

Actin is a ubiquitously expressed protein in both eukaryotes and prokaryotes. Monomers of actin polymerize into actin filaments and represent one of the three major components of the cellular cytoskeleton, also including microtubules and intermediate filaments. The discovery of the protein actin preceded the discovery of actin filaments and is dated back to the end of the 1800s, in terms of its earliest detection. The initial detection of actin was performed using vertebrate muscle tissue wherein it is in great abundance. The complete sequence of actin was initially described at a Cold Spring Harbor Symposium in 1971 and subsequently published in 1973. The solution of the structure of actin greatly benefited from the unexpected observations that actin formed high-affinity complexes with deoxyribonuclease I (DNase I) and profilin, the latter being a protein with now well-understood roles in the regulation of actin biology, while the significance of the...

Keywords

Crystallization Migration Tyrosine Serine Cytosol 
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Anatomy and Cell Biology, Shriners Pediatric Research CenterLewis Katz School of Medicine, Temple UniversityPhiladelphiaUSA