Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Granzyme B

  • Christopher T. Turner
  • Valerio Russo
  • Stephanie Santacruz
  • Cameron Oram
  • David J. Granville
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101961-1


Historical Background

Perforin, a Ca2+-dependent pore forming protein found in the granules of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), was once proposed to be “the sole mediator of target cell destruction” (Ewen et al. 2012). However, in the late 1970s perforin was revealed to lack the protease activity required for apoptotic induction (Ewen et al. 2012). To identify other proteases that may be responsible, multiple researchers independently investigated the composition of CTL and NK cell granules (Boivin et al. 2009). Percoll density gradients were used to separate granules from NK cells and gel filtration then removed perforin, leaving an enriched pool of serine proteases. These “granule-associated enzymes” were subsequently named granzymes (Masson and Tschopp 1987). Cation exchange chromatography separated the granzymes into distinct clusters as...


Natural Killer Cell Aortic Aneurysm Kawasaki Disease Giant Cell Arteritis Cardiac Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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The authors wish to apologize to the many authors involved in studies that were uncited in this article and acknowledge that numerous references were not included due to space/reference limitation. Many of the references therefore refer to review articles where the original studies are cited.


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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Christopher T. Turner
    • 1
  • Valerio Russo
    • 1
  • Stephanie Santacruz
    • 1
  • Cameron Oram
    • 1
  • David J. Granville
    • 1
  1. 1.Granville Laboratory, ICORD, Faculty of MedicineUniversity of British ColumbiaVancouverCanada