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Caveolin-1

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Encyclopedia of Signaling Molecules

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  • Arpaia E, Blaser H, Quintela-Fandino M, et al. The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src Ras and Erk. Oncogene. 2012;31(7):884–96. doi:10.1038/onc.2011.288.

    Article  CAS  PubMed  Google Scholar 

  • Chatterjee M, et al. Caveolin-1 is associated with tumor progression and confers a multi-modality resistance phenotype in pancreatic cancer. Sci Rep. 2015;5:10867. doi:10.1038/srep10867.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen D, Che G. Value of caveolin-1 in cancer progression and prognosis: emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review). Oncol Lett. 2014;8(4):1409–21. doi:10.3892/ol.2014.2385.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cohen AW, Hnasko R, Schubert W, Lisanti MP. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004;84(4):1341–79.

    Article  CAS  PubMed  Google Scholar 

  • Echarri A, Del Pozo MA. Caveolae – mechanosensitive membrane invaginations linked to actin filaments. J Cell Sci. 2015;128:2747–58. doi:10.1242/jcs.153940.

    Article  CAS  PubMed  Google Scholar 

  • Engelman JA, Zhang XL, Lisanti MP. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). FEBS Lett. 1999;448:221–30. doi:10.1016/S0014.

    Article  CAS  PubMed  Google Scholar 

  • Glenney Jr JR. Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus. J Biol Chem. 1989;264(34):20163–6.

    CAS  PubMed  Google Scholar 

  • Hoop CL, Sivanandam VN, Kodali R, Srnec MN, van der Wel PCA. Structural characterization of the caveolin scaffolding domain in association with cholesterol-rich membranes. Biochemistry. 2012;51(1):90–9. doi:10.1021/bi201356v.

    Article  CAS  PubMed  Google Scholar 

  • Huang C, Qiu Z, Wang L, et al. A novel FoxM1-Caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 2012;72(3):655–65. doi:10.1158/0008-5472.CAN-11-3102.

    Article  CAS  PubMed  Google Scholar 

  • Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, Wilson MT, Campos-Gonzalez R, Bouzahzah B, Pestell RG, Scherer PE, Lisanti MP. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol. 2000;14(11):1750–75.

    Article  CAS  PubMed  Google Scholar 

  • Liu P, Rudick M, Anderson RGW. Multiple functions of caveolin-1. J Biol Chem. 2002;277:41295–8.

    Article  CAS  PubMed  Google Scholar 

  • Lobos-González L, Aguilar L, Diaz J, et al. E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells. Pigment Cell Melanoma Res. 2013;26(4):555–70. doi:10.1111/pcmr.12085.

    Article  PubMed  PubMed Central  Google Scholar 

  • Luanpitpong S, Wang L, Stueckle TA, Tse W, Chen YC, Rojanasakul Y. Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget. 2014;5(11):3541–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Quest AFG, Gutierrez-Pajares JL, Torres VA. Caveolin-1: an ambiguous partner in cell signaling and cancer. J Cell Mol Med. 2008;12(4):1130–50. doi:10.1111/j.1582-4934.2008.00331.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rodriguez DA, Tapia JC, Fernandez JG, et al. Caveolin-1-mediated suppression of cyclooxygenase-2 via a β-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell. 2009;20(8):2297–310. doi:10.1091/mbc.E08-09-0939.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Routray S. Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview. Tumor Biol. 2014;35:9487–95. doi:10.1007/s13277-014-2482-z.

    Article  CAS  Google Scholar 

  • Stan RV. Structure of caveolae. Biochim Biophys Acta. 2005;1746:334–48.

    Article  CAS  PubMed  Google Scholar 

  • Torres VA, Tapia JC, Rodriguez DA, et al. E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced β-catenin-Tcf/Lef-dependent transcription. Mol Cell Biol. 2007;27(21):7703–17. doi:10.1128/MCB.01991-06.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van den Heuvel APJ, Schulze A, Burgering BMT. Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J. 2005;385(Pt 3):795–802. doi:10.1042/BJ20041449.

    PubMed  PubMed Central  Google Scholar 

  • Williams TM, Lisanti MP. The caveolin proteins. Genome Biol. 2004;5:214.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Samapika Routray .

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Routray, S., Swain, N., Hosalkar, R.M. (2017). Caveolin-1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101931-1

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