Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101926-1


Background and Discovery of WISP1

Wnt-1 inducible signaling pathway protein 1 (WISP1) is an exciting target for the development of new treatments against acute and chronic disorders that may involve cellular metabolism as well as the nervous, musculoskeletal, cardiac, pulmonary, and vascular systems (Maiese 2014) (Fig. 1). WISP1 also is known as CCN4 and is a member of the CCN family of proteins. The CCN family of proteins consists of six secreted extracellular matrix-associated proteins and is defined by the first three members of the family that include cysteine-rich protein 61, connective tissue growth factor, and nephroblastoma overexpressed gene. Each family member has four cysteine-rich modular domains that...


Stem Cell Proliferation Forkhead Transcription Factor Growth Plate Cartilage Promote Cell Cycle Progression Vascular Smooth Muscle Proliferation 
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This research was supported by the following grants to Kenneth Maiese: American Diabetes Association, American Heart Association, NIH NIEHS, NIH NIA, NIH NINDS, and NIH ARRA.


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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Cellular and Molecular SignalingNewarkUSA