Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

GLI Family Zinc Finger 2

  • David A. Jackson
  • Jason A. Misurelli
  • Sherine F. Elsawa
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101917-1

Synonyms

Historical Background

GLI2 belongs to the GLI family of genes, encoding Kruppel-like zinc finger transcription factors. Evidence for GLI proteins and their function was first elucidated through the characterization of the Drosophila GLI homolog Cubitus interruptus (Ci), responsible for proper tissue patterning and segmentation (Goodrich et al. 1996). While highly conserved, vertebrates have three different forms of the transcription factor (GLI1, GLI2, and GLI3), each taking on redundant and unique roles in normal and pathologic biology. GLI1, the first of the GLI family characterized in humans, was identified in 1987 as a highly expressed gene in human glioma (Kinzler et al. 1987). Both GLI2 and GLI3 were discovered in 1988 through the use of cloned GLI1 cDNA as a probe targeting similar sequences (Ruppert et al. 1988). The expression of...

Keywords

Basal Cell Carcinoma Arsenic Trioxide Lung Squamous Cell Carcinoma GLI2 Expression Lung Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • David A. Jackson
    • 1
  • Jason A. Misurelli
    • 1
  • Sherine F. Elsawa
    • 1
  1. 1.Department of Biological SciencesNorthern Illinois UniversityDeKalbUSA