Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

AMP-Activated Protein Kinase (AMPK)

  • Gopinath Prakasam
  • Mohammad Askandar Iqbal
  • Rajnish Kumar Singh
  • Rameshwar N.K. Bamezai
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101894-1

Synonyms

Historical Background

AMPK (5′ adenosine monophosphate-activated protein kinase) (EC; 2.7.11.31) is a cellular energy sensor that is activated by increased intracellular levels of AMP or ADP produced as a result of unrestrained ATP hydrolysis, thus representing scarcity of cellular ATP. AMPK, therefore, allows adaptation to low energy conditions to preserve the cellular energy homeostasis and in response increases catabolism to generate more ATP. Besides acting as a sensor for intracellular metabolic stress signals, due to nutritional insufficiency and hypoxia, AMPK also gets activated by an array of physiological stimulations, including calcium concentration via calmodulin kinase (CAMKKβ), action of various hormones, and cytokines. In brief, once activated by sensing the falling energy (ATP) status, it...

Keywords

Cholesterol Lipase Doxorubicin Triglyceride Etoposide 
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Gopinath Prakasam
    • 1
  • Mohammad Askandar Iqbal
    • 1
    • 2
  • Rajnish Kumar Singh
    • 1
    • 3
  • Rameshwar N.K. Bamezai
    • 1
  1. 1.National Center for Applied Human Genetics, School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Department of Biotechnology, Faculty of Natural SciencesJamia Millia IslamiaNew DelhiIndia
  3. 3.Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA