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Retinol-Binding Protein 4 (RBP4)

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Encyclopedia of Signaling Molecules

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References

  • Abel ED, Peroni O, Kim JK, Kim Y-B, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001;409(6821):729–33.

    Article  CAS  PubMed  Google Scholar 

  • Berry DC, Jin H, Majumdar A, Noy N. Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci. 2011;108(11):4340–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bustin M, Reeves R. High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. Prog Nucleic Acid Res Mol Biol. 1996;54:35–100b.

    Article  CAS  PubMed  Google Scholar 

  • Chiefari E, Paonessa F, Iiritano S, Le Pera I, Palmieri D, Brunetti G, Lupo A, Colantuoni V, Foti D, Gulletta E. The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis. BMC Biol. 2009;7(1):1.

    Article  Google Scholar 

  • De Caterina R, Ghiadoni L, Taddei S, Virdis A, Almerigogna F, Basta G, Lazzerini G, Bernini W, Salvetti A. Soluble E-selectin in essential hypertension: a correlate of vascular structural changes*. Am J Hypertens. 2001;14(3):259–66.

    Article  CAS  PubMed  Google Scholar 

  • Deng W, Zhang Y, Zheng Y, Jiang Y, Wu Q, Liang Z, Yang G, Chen B. Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients. Diabetol Metab Syndr. 2014;6(1):72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma J-x. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase-and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(24):5103–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med. 2005;11(7):765–73.

    Article  CAS  PubMed  Google Scholar 

  • Graham TE, Yang Q, BlĂĽher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354(24):2552–63.

    Article  CAS  PubMed  Google Scholar 

  • Jessen KA, Satre MA. Induction of mouse retinol binding protein gene expression by cyclic AMP in Hepa 1–6 cells. Arch Biochem Biophys. 1998;357(1):126–30.

    Article  CAS  PubMed  Google Scholar 

  • Kotnik P, Fischer-Posovszky P, Wabitsch M. RBP4: a controversial adipokine. Eur J Endocrinol. 2011;165(5):703–11.

    Article  CAS  PubMed  Google Scholar 

  • Li F, Xia K, Sheikh MSA, Cheng J, Li C, Yang T. Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation. Endocrine. 2015;48(2):472–482.

    Google Scholar 

  • Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(10):2010–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ă–st A, Danielsson A, LidĂ©n M, Eriksson U, Nystrom FH, StrĂĄlfors P. Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes. FASEB J. 2007;21(13):3696–704.

    Article  PubMed  Google Scholar 

  • Polonsky KS, Sturis J, Bell GI. Non-insulin-dependent diabetes mellitus—a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med. 1996;334(12):777–83.

    Article  CAS  PubMed  Google Scholar 

  • Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem. 1993;268(30):22243–6.

    CAS  PubMed  Google Scholar 

  • Soprano D, Blaner W. Plasma retinol-binding protein. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry and medicine. New York: Raven Press; 1994.

    Google Scholar 

  • Von Eynatten M, Humpert PM. Retinol-binding protein-4 in experimental and clinical metabolic disease. Expert Rev Mol Diagn. 2008;8(3):289–99.

    Article  CAS  PubMed  Google Scholar 

  • Wolf G. Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev. 2007;65(5):251–6.

    Article  PubMed  Google Scholar 

  • Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436(7049):356–62.

    Article  CAS  PubMed  Google Scholar 

  • Zabetian-Targhi F, Mahmoudi MJ, Rezaei N, Mahmoudi M. Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases. ADV NUTR. 2015;6(6):748–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia

    Fateme Zabetian-Targhi

  2. Department of Cellular Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Maryame Mahmoudi

  3. Pediatric Gastroenterology and Hepatology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Maryame Mahmoudi

  4. Dietetics and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Maryame Mahmoudi

Authors
  1. Fateme Zabetian-Targhi
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  2. Maryame Mahmoudi
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Corresponding author

Correspondence to Maryame Mahmoudi .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Zabetian-Targhi, F., Mahmoudi, M. (2016). Retinol-Binding Protein 4 (RBP4). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101853-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101853-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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