Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Retinol-Binding Protein 4 (RBP4)

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101853-1


Historical Background

Retinol-binding protein 4 (RBP4), previously known as RBP, is a career of retinol in plasma that transport retinol from liver to peripheries. This protein mainly produced by liver and partly from adipose tissue RBP4 is encoded by the Rbp4 gene, localized in the chromosome 10q23-q24 including 8 exons. The lack of RBP4 leads to vitamin A deficiency in Rbp4 knockout mice. RBP4 that is not bound to retinol is called as Apo-RBP4, whereas retinol-bound RBP4 (holo- RBP4) associates with transthyretin (TTR) in plasma in order to stop RBP to be lost during kidney filtration. Stimulated by retinoic acid 6 (STRA6) is the cell surface receptor for RBP4. For years RBP4 was known just as a vitamin A career and a negative phase marker of acute inflammation; however, recent studies provided a novel insight to RBP4 and its role in inflammation and obesity-related complications including insulin...


RBP4 Level RBP4 Concentration Adipose Tissue Gene Expression RBP4 Gene RBP4 mRNA 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Menzies Institute for Medical ResearchUniversity of TasmaniaHobartAustralia
  2. 2.Department of Cellular Molecular Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran
  3. 3.Pediatric Gastroenterology and Hepatology Research Center, Children’s Medical CenterTehran University of Medical SciencesTehranIran
  4. 4.Dietetics and Nutrition Experts Team (DiNET)Universal Scientific Education and Research Network (USERN)TehranIran