Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

B Lymphocyte Antigen CD19

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101837-1

Synonyms

Historical Background

CD19 was first identified as biomarker of normal and neoplastic B lymphocytes as B4 antigen with the use of anti-B4 monoclonal antibody against CD19 (Anderson et al. 1984). Anti-B4 antibody in turn was encoded from cDNA clones of human tonsillar cDNA library, by selectively hybridizing with RNA from CD19+ cell lines. Both human and mouse CD19 molecules are highly homologous with a conserved cytoplasmic domain with no homology with other known proteins and an immunoglobulin-like extracellular domain, which gave CD19 molecule the status of a member of Ig superfamily (Tedder and Isaacs 1989).

Introduction

The CD19 molecule is a 95 KDa cell surface protein of B lymphocytes and follicular dendritic cells (FDC). It is considered as a biomarker of B cell because of its continued expression throughout B cell differentiation stages starting from late pro-B cell stage until terminally differentiated plasma cells (Nadler et al. 1983;...

Keywords

Chimeric Antigen Receptor CD19 Gene Common Variable Immunodeficiency Germinal Center Formation CD19 Surface Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Nanomaterial Therapeutics and Toxicology GroupCSIR-Indian Institute of Toxicology Research (CSIR-IITR)LucknowIndia