S6K (S6 Kinase)
The ribosomal S6 protein kinases (S6Ks) represent a superfamily of proteins which were originally discovered to phosphorylate ribosomal protein S6. Proteins known as p90 ribosomal S6 kinases (RSKs) have been first identified as able to phosphorylate ribosomal protein S6 (Jones et al. 1988). A short time later, S6K1 protein was discovered gaining a major role in S6 phosphorylation in somatic cells, while RSKs gained less significance in this process (Banerjee et al. 1990). It is important to note that RSKs and S6Ks belong to different subfamilies of serine/threonine kinases but...
KeywordsNuclear Localization Signal Murine Double Minute Eukaryotic Translation Initiation Factor Increase S6K2 Phosphorylation eIF4B Phosphorylation
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