Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Heat Shock Protein (HSP)

  • Betul Karademir
  • Gulce Sari-Kaplan
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101809-1


There are synonyms of each HSP members in mammals: DNAJ: HSP40; HSPA: HSP70; HSPB: small HSP families; Human chaperonin families: HSP60 and CCT; HSPC: HSP90; HSPH: HSP110 (Kampinga et al. 2009).

The cellular and species-specific isoforms are given in each part of the text.

Historical Background

Heat shock proteins (HSPs) were first described by Ritossa (1962) in Drosophila (Drosophila busckii and Drosophila melanogaster) in response to temperature, and the active genes coding HSPs are called puffs. Ritossa (1962) also showed increased expression of HSPs following 2,4-Dinitrophenol (DNP) treatment instead of temperature (Ritossa 1962). Later, Koninkx (1976) decided to analyze all inducing conditions of HSPs in Drosophila, so he studied several stress conditions on different tissues and finally reported that puffs could be detected under different stress conditions not only temperature changes. Koninkx (1976) also used the term “heat shock proteins” for puff patterns (Koninkx 1976...


Heat Shock Factor Client Protein Apical Domain Middle Domain DnaJ Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Medical BiochemistryMarmara University School of MedicineMaltepe, IstanbulTurkey